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Clinical Outcomes and Hospital Resource Utilization Among Patients with Sepsis and COVID-19 Infection: Insights from the United States National Inpatient Sample Analysis, 2020–2022

Background/Objectives: Clinical studies have shown that patients who had sepsis with COVID-19 infection had worse clinical outcomes; however, there is a paucity of data on the association between concurrent COVID-19 infection and outcomes among patients with sepsis. Hence, we con...

CNP-miR146a Promotes NRF2-Related Ferroptosis-Protective Myeloid Programs and Immune–Vascular Regeneration in Diabetic Wounds

Background: Diabetic wounds are characterized by chronic inflammation, oxidative stress, impaired angiogenesis, and delayed tissue repair. Ferroptosis has emerged as a potential contributor to diabetic wound pathology; however, its relationship with impaired tissue regeneration r...

Cost-Effectiveness of Endovascular vs Open Surgery for Chronic Limb-Threatening Ischemia

Importance: Choosing between endovascular and open (bypass) surgical revascularization for chronic limb-threatening ischemia has major implications for clinical practice. Objective: To evaluate the cost-effectiveness of endovascular vs bypass surgical revascularization. Design, S...

Thirty-day Mortality Among Jehovah's Witness Patients with Gastrointestinal Bleeding Who Decline Blood Transfusion: A Retrospective Cohort Study

INTRODUCTION: Patients with acute gastrointestinal bleeding (GIB) who decline allogeneic blood transfusion present a major management challenge, and comparative outcome data are limited. METHODS: We conducted a multicenter retrospective propensity score-matched cohort study acros...