Baker Heart and Diabetes Institute

Effect of Testosterone Treatment on Leucocyte Telomere Length in Men: Results From a Randomised Placebo‐Controlled Trial

BACKGROUND: Lower testosterone concentrations in older men are associated with poorer health outcomes. OBJECTIVE: We examined whether, on a background of lifestyle intervention, testosterone treatment modulates leucocyte telomere length, a postulated marker of biological ageing,...

Prevalence, Incidence and Mortality of Chronic Kidney Disease in Type 1 and Type 2 Diabetes—A Nationwide Danish Register‐Based Cohort Study

ABSTRACT Aims Chronic kidney disease (CKD) remains a leading complication of diabetes, and understanding population‐level trends is crucial for prevention and healthcare planning. We examined national trends in CKD prevalence, incidence, and mortality among people with diabetes....

Long-term type 2 diabetes risk prediction using machine learning with childhood, adolescent, and genetic factors

Abstract Late diagnosis of type 2 diabetes increases patient morbidity and healthcare burden, yet current prediction models use adult risk factors to estimate 5–10-year risk. In this manuscript, we evaluate long-term prediction of type 2 diabetes over 38 years using childhood fac...

Terminology for describing the 24-h cycle of physical activity, sedentary behaviour, and sleep: a scoping review

Abstract Background Physical activity, sedentary behaviour, and sleep are three behaviours which occupy the 24-h cycle and interact to influence a multitude of health outcomes. Different terms are currently used to describe these behaviours collectively (e.g., movement behaviours...

Lipids and apolipoproteins affect the risk of ST-elevation and non-ST-elevation myocardial infarctions differently in type 1 diabetes: a nationwide finnish cohort study

Non-ST-elevation myocardial infarction (NSTEMI) has become the main myocardial infarction subtype in type 1 diabetes compared to ST-elevation myocardial infarction (STEMI), accounting for nearly 80% of myocardial infarction-related hospitalizations. Yet, prior studies in type 1 d...