Badr University in Cairo

Mechanistic attenuation by L-carnitine of trastuzumab-induced downregulation of adenosine monophosphate -activated protein kinase signal in cardiac H9c2 cells

Clinical usefulness of trastuzumab (TZ) is restrained owing to its cardiotoxic effect. This investigation was initiated to evaluate the potential protective impact of carnitine (CARN) against TZ-related cardiac influence; and to uncover the underlining mechanism. Cytotoxic effect...

A novel real-time integrated adaptive stable offloading (RIASO) algorithm in multi-access edge computing

Abstract Mobile Edge Computing (MEC) and Mobile Computation Offloading (MCO) help IoT devices with limited computational capabilities and battery by offloading tasks to the nearest resource-rich servers in MEC. Deciding to execute the tasks at the user device or the edge server c...

Antimicrobial Resistance in E. coli and Salmonella spp. Across Romanian Animal–Food–Environment Interfaces: Current Evidence and One Health Knowledge Gaps

Antimicrobial resistance (AMR) is an important One Health challenge, yet evidence on resistant Escherichia coli and Salmonella spp. in Romania is dispersed across animal species, food matrices, environmental compartments, and surveillance systems. This comprehensive narrative rev...

Targeting mitochondrial dysfunction and apoptosis in 5-fluorouracil–induced cardiotoxicity using kaempferol-mediated selenium nanoparticles

Abstract 5-Flurouracil (5-FU) is still considered as one of the most popular antimetabolite chemotherapy drugs to treat a wide variety of solid tumors. Dose limiting toxicity on major organs, especially cardiovascular system limits the therapeutic use of 5-FU. The current paper a...

Evaluation of the new Egyptian undergraduate medical program from students’ perspectives: a nationwide cross-sectional study

Abstract Background The global emphasis on medical education reform highlights the need for essential competencies to meet evolving healthcare demands. In Egypt, significant reforms in 2018 introduced a competency-based, integrated undergraduate medical curriculum—a five-year pro...

A preliminary antimicrobial investigation of lactobacillus bulgaricus probiotic supernatants as an intracanal medication against mature E. faecalis biofilm in an ex-vivo dentin blocks model

AIM: To provide a preliminary assessment of the antimicrobial potential of Lactobacillus bulgaricus probiotic against mature Enterococcus faecalis biofilm in dentin model under ex-vivo conditions using confocal laser scanning microscopy (CLSM). METHODS: Lactobacillus bulgaricus a...

Optimizing service accessibility using GIS-driven and genetic algorithms for sustainable neighborhoods

Urbanization has accelerated globally, with over half of the world’s population now residing in cities. This rapid growth underscores urbanization’s role as a catalyst for economic development and underscores the need for sustainable, accessible neighborhoods. This research aims...

Evaluation of the new Egyptian undergraduate medical program from the perspectives of faculty and institutional leadership: a nationwide, mixed-method study

Abstract Background In response to global calls for medical education reform, Egypt restructured its national undergraduate medical education program from a 6 + 1 model to a competency-based “5 + 2” model. This reformed program emphasizes early clinical exposure, integration of b...

Microbial and Enzymatic Transformation of Per- and Polyfluoroalkyl Substances (PFAS): From Defluorination and Biological Partitioning to a Separation-First Biological Treatment Framework

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants. Conventional destructive technologies, such as advanced oxidation and electrochemical processes, can achieve partial or complete defluorination. However, their high energy demand, chemical inputs,...

Effect of diode laser on micro-tensile bond strength of hybrid ceramic restorations to dentin using one-step and two-step self-etch adhesives: in vitro study

Abstract Background This study aimed to evaluate the effect of diode laser irradiation on the micro-tensile bond strength (µTBS) of hybrid ceramic restorations bonded to dentin using one-step and two-step self-etch adhesives. Methods An in vitro study was conducted using 20 fresh...