Bachem (Switzerland)

Anisotropic Electrostaticsin the Instability of GLP-1Analog Micelles: Effects of Electrolytes, Denaturants, pH, and Temperature

Abstract Glucagon-like peptide-1 (GLP-1) analogs (GLPA) exist primarily as micelle-like associations when free in aqueous solution. The results here indicate that anisotropic electrostatic interactions play a central role in the instability and aggregation, which appear to arise...