Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Real-World Antibiotic Strategies for Multidrug-Resistant Pseudomonas aeruginosa: Evidence from the Italian SUSANA Multicentre Study

Background/Objectives: Multidrug-resistant (MDR) Pseudomonas aeruginosa pneumonia and bloodstream infections (BSI) remain challenging because of their severity, limited therapeutic options, and high mortality, despite the availability of novel β-lactam-based agents. We aimed to d...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Liver Transplantation Following Hepatocellular Carcinoma Rupture and Long-Term Immunotherapy: A Case Report

Abstract Aim To report a case of advanced hepatocellular carcinoma (HCC) complicated by tumor rupture, successfully downstaged with combined oncolytic immunotherapy (Pexa-Vec) and a PD-1 inhibitor (Nivolumab), ultimately enabling liver transplantation (LT). This report highlights...

Use of the Il-1 Inhibitor (Anakinra) for the Treatment of Acute Myocarditis in Pediatric Patients: A Single-Center Experience

Objectives Myocarditis is an acute inflammatory process of the myocardium characterized by impaired contractile function. The incidence is 1-2 cases/100,000 children, but it has increased since 2020 due to Pediatric Multisystem Inflammatory Syndrome (MIS-C). The pathogenesis invo...