Azienda Socio Sanitaria Territoriale di Bergamo Ovest

Treatment-Induced PD-L1 Dynamics and Temporal Heterogeneity in Locally Advanced and Metastatic Gastroesophageal Cancer—A Systematic Review

Background/Objectives: Standard guidelines for treating locally advanced and metastatic gastroesophageal cancer (GEC) involve combination regimens of chemotherapy and immunotherapy. Patient eligibility for these treatments is primarily guided by the programmed cell death ligand 1...

Management of Advanced Solid Tumors Recurring After Adjuvant Immune Checkpoint Inhibitors: A Structured Narrative Review

Adjuvant and perioperative immune checkpoint inhibitors (ICIs) have created a growing population of patients who relapse after prior programmed death-1 or programmed death-ligand 1 blockade, yet these patients were underrepresented in many trials that established metastatic stand...