Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

Patient acceptance and experience with contrast-enhanced mammography in women with a personal history of breast cancer: findings from the COMBO trial

Abstract Objectives To evaluate patient acceptance, tolerability and experience with contrast-enhanced mammography (CEM) in women with a personal history of breast cancer undergoing routine post-surgical surveillance. Materials and methods This prospective cohort study, conducted...

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

Organizing healthcare delivery in the era of disease-modifying therapies for Alzheimer’s Disease: an Italian RAND/UCLA consensus

BACKGROUND: Alzheimer's disease (AD) poses a growing clinical and organizational challenge, requiring coordinated, multidisciplinary care models. In Italy, significant regional variability in resources and access to diagnostic services persists, while the implementation of commun...

Community-based monitoring of neonatal jaundice using the point-of-care Bilistick® System 2.0

Neonatal jaundice often peaks after discharge, creating the need for reliable post-discharge monitoring. This study evaluated the feasibility and safety of a hospital-to-community pathway using the Bilistick® System 2.0 within routine Community Health Family Services (CHFS). This...

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

Impact of blood pressure variability on mortality risk of patients with ANCA-associated vasculitis

Abstract Objectives Antineutrophil cytoplasmic antibody–associated vasculitis (AAV) is associated with increased cardiovascular risk, related to persistent inflammation and endothelial dysfunction. Long -term systolic BP variability (SBPV), reflecting vascular damage, may predict...

Everything you always wanted to know about sleep, but you were afraid to ask: expert concise guide and recommendations on assessing sleep-wake disturbances within a psychiatric context in contemporary times

OBJECTIVE: While disrupted sleep has long been linked to mental disorders there has been a notable decrease in interest and sleep-wake disorders have received low priority in psychiatric care. The aim of the paper was to present a concise guide for evaluating common sleep-wake di...

Single-dose versus short-course antibiotic prophylaxis in laparoscopic right hemicolectomy with intracorporeal anastomosis: a retrospective cohort study

To date, data on effectiveness of different antibiotic prophylaxis protocols on surgical site infections (SSI) after laparoscopic right colectomy with intracorporeal anastomosis (LRC-IA) are scarce. The aim of this double-centers retrospective study was to compare 30-day Organ/Sp...

Overwhelming post-splenectomy Capnocytophaga canimorsus infection complicated by suspected infection-associated secondary thrombotic microangiopathy with a complement-mediated hemolytic uremic syndrome phenotype and extensive tissue necrosis after a dog bite

Capnocytophaga canimorsus is a rare zoonotic pathogen that can cause fulminant sepsis in asplenic patients, including overwhelming post-splenectomy infection after dog bites. Its association with suspected infection-associated secondary thrombotic microangiopathy with a complemen...

Migraine in Real-World Clinical Practice: Patient Burden, Healthcare Utilization and Unmet Needs—A Cross-Sectional Analysis of the I-GRAINE Study

What are the main findings?Migraine care in Italy is characterized by a mismatch between healthcare resource utilization and clinical needs, with limited primary-care involvement, repeated specialist consultations, and healthcare nomadism.Healthcare resource utilization is substa...

Postpandemic Trends in Pediatric Respiratory Virus Hospitalizations: A Multicenter Study, 2019–2025

ABSTRACT Background The COVID‐19 pandemic profoundly altered the circulation of respiratory viruses in children, changing the epidemiology of acute lower respiratory tract infections. In the postpandemic period, respiratory pathogens showed marked temporal variability. The 2024–2...

A survey on the institutional practices of the use of isavuconazole in onco-hematological children, on behalf of the Infectious Working Group of AIEOP

Isavuconazole is a broad-spectrum antifungal agent approved for the treatment of invasive fungal infections (IFIs) in adults and, recently, in pediatric patients aged 1 year and older. Use in the pediatric setting remains limited, but available data indicate generally favorable s...

Antibody-Dependent Cellular Phagocytosis and Cytotoxicity in Patients With LGI1 and CASPR2 Encephalitis

This database includes the raw data linked with the paper “ Antibody-dependent cellular-phagocytosis and -cytotoxicity in patients with LGI1 and CASPR2 encephalitis”. Objective: Antibodies against LGI1 and CASPR2 (LGI1/CASPR2-IgG) associate with forms of autoimmune encephalitis (...

Quantitative framework for synthesising defocus-curve evidence in simultaneous-vision intraocular lenses

Background/aims To develop a quantitative, meta-analytic framework to synthesise defocus-curve evidence and describe functional visual performance of simultaneous vision intraocular lenses (SVIOLs) across clinically relevant visual ranges. Methods PubMed was searched from incepti...

Neoplasms Metastatic to the Larynx: A Systematic Review

Metastatic involvement of the larynx from nonhead and neck primary tumors is an exceptionally rare event, frequently misdiagnosed as a primary laryngeal lesion and at risk of inappropriately aggressive surgical management. This systematic review aimed to define the most common pr...

Rehabilitation and the post-intensive care syndrome across the recovery continuum: a narrative review

Purpose Improved survival from critical illness has produced a growing population of intensive care unit (ICU) survivors with new or worsened physical, cognitive, and mental-health impairment, defined as post-intensive care syndrome (PICS), and frequent distress among families/ca...

Time‐Dependent Diagnostic Yield and Therapeutic Impact of Implantable Loop Recorders, Brugada Syndrome as the Exception

ABSTRACT Introduction The optimal duration of implantable loop recorder (ILR) monitoring remains uncertain and may differ according to the indication for implantation. We evaluated whether the time‐dependent diagnostic yield and clinical relevance of ILR‐detected arrhythmias diff...

Toward harmonized reporting of Alzheimer’s disease biomarkers in clinical practice

Abstract Cerebrospinal fluid biomarkers, and more recently blood-based biomarkers, are playing a pivotal role in reshaping the clinical management of neurodegenerative diseases, supporting early detection, biological diagnosis, patient stratification, prognostic assessment, thera...

Summary of Research: Brentuximab Vedotin and Nivolumab in Combination with Chemotherapy for Nonbulky, Early-Stage Classical Hodgkin Lymphoma

This is a summary of the original research article “Brentuximab Vedotin and Nivolumab in Combination with Chemotherapy for Nonbulky, Early-Stage Classical Hodgkin Lymphoma.” The phase 2 SGN35-027 study (NCT03646123) is a multiple-part clinical trial of brentuximab vedotin (BV), w...

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry

BACKGROUND: Cancer represents a major cause of mortality in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti-RNA polymerase III (POLR3)-positive disease, needing further exploration. METHODS: We performed a nested...