Azienda Sanitaria Unità Locale di Reggio Emilia

Interstitial Lung Abnormalities: A Multidisciplinary Narrative Review

Abstract Interstitial lung abnormalities (ILAs) is an umbrella term used to describe a spectrum of computed tomography (CT)-detected lung abnormalities that may reflect interstitial lung disease (ILD). Initially perceived as a niche topic—and often underreported in clinical pract...

Hoof Health in the Parmigiano Reggiano Dairy Production System: A Pilot Epidemiological Study Using Digitally Recorded Hoof-Trimming Data

The aim of this study was to describe the prevalence and distribution of claw lesions in dairy cows from farms producing milk for Parmigiano Reggiano cheese and to evaluate factors associated with their occurrence. Data were collected during hoof-trimming visits performed by four...

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

Self-medication as metaphor: why psychiatry should revise an (in) convenient narrative about substance use and mental disorders

Summary The term self-medication remains an influential narrative to explain why some patients with mental health problems use psychoactive substances. This Feature offers a conceptual critique of its broad use in psychiatry. We argue that self-medication often functions less as...

Cardiac Complications of Infections Due to Respiratory Syncytial Virus and Human Metapneumovirus: A Systematic Review and Pooled Analysis of Clinical Features

Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are major causes of respiratory tract infections across different age groups. Although primarily regarded as respiratory pathogens, both viruses have been associated with cardiac complications, whose clinical spec...

I casi studio per testare utilità e validità dell'Atlante Aria Salute: definizione del quadro concettuale.

OBJECTIVES: to describe the process of selecting and applying a shared conceptual model for the analysis of case studies designed to test the usefulness and validity of the Air and Health Atlas in supporting decision-making, in its current version and in its potential future deve...

Migraine in Real-World Clinical Practice: Patient Burden, Healthcare Utilization and Unmet Needs—A Cross-Sectional Analysis of the I-GRAINE Study

What are the main findings?Migraine care in Italy is characterized by a mismatch between healthcare resource utilization and clinical needs, with limited primary-care involvement, repeated specialist consultations, and healthcare nomadism.Healthcare resource utilization is substa...

The Italian Version of the Lesbian, Gay, Bisexual and Transgender Development of Clinical Skills Scale (LGBT-DOCSS): Validation Among Mental Health Professionals

INTRODUCTION: Sexual and gender minority (SGM) individuals experience substantial health inequalities, and clinical competence among healthcare providers is a key determinant of equitable care. The Lesbian, Gay, Bisexual and Transgender Development of Clinical Skills Scale (LGBT-...

Development of a prospective clinical workflow for proton beam therapy of ventricular tachycardia

Abstract Purpose This study presents a prospective preclinical workflow for proton beam therapy of refractory ventricular tachycardia (VT), covering target transfer, treatment planning (TP), and beam gating. Methods Photon-based stereotactic arrhythmia radioablation (STAR) protoc...

Beta Atlas: Charting Global Production of Nonconventional β − -Emitters for Targeted Radiopharmaceutical Therapy—Part 1

β-minus particle (β−)–emitting radionuclides have long been central to targeted radiopharmaceutical therapy. Interest in expanding their repertoire beyond conventional options has grown over time, as the need for radionuclides with different emission profiles and theranostic pote...

Pregnancy Deciduosis Mimicking Abdominal Tuberculosis and Peritoneal Carcinomatosis: A Case Report

Background and clinical significance: Gestational deciduosis is a benign, progesterone-related ectopic decidual reaction that commonly involves pelvic and peritoneal surfaces and usually regresses after delivery. Although generally asymptomatic, diffuse peritoneal deciduosis may...

The Association Between Muscle Strength, Thigh Circumference, and Serving Efficiency in Elite Male Volleyball Players: A Prospective Observational Longitudinal Study

Background and Aim: The identification of factors that optimize competitive performance is a primary focus for athletes and coaches in any sport, particularly variables that are modifiable through tailored nutritional and training strategies. Since data regarding volleyball remai...

Radiotherapy in Combination with CD20×CD3 Bispecific Antibodies for B-Cell Lymphoma: Biological Rationale, Current Evidence, and Open Questions

Background/Objectives: CD20×CD3 bispecific antibodies (BsAbs) have changed the management of relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma. Whether and how radiotherapy (RT) can be safely and usefully combined with BsAb therapy remains undefined. This Perspective reviews...

Pacemaker Implantation in Patients With Syncope, Bundle Branch Block and Negative Electrophysiological Study

ABSTRACT Introduction The long‑term need for permanent pacemaker (PM) implantation in patients with syncope, bundle branch block (BBB), and a negative electrophysiological study (EPS) is not well defined. Methods and Results We retrospectively analyzed consecutive patients underg...

Fatal waterhouse–friderichsen syndrome at autopsy: a systematic review and forensic diagnostic framework

Waterhouse-Friderichsen syndrome (WFS) represents a fulminant septic condition characterized by bilateral adrenal hemorrhage and rapid clinical deterioration. Although classically associated with meningococcal infection, fatal cases occur across multiple infectious etiologies and...

Reproducibility of Cervical Strain Elastography Using a Standardized Acquisition Protocol in Mid‐Trimester Pregnancy

ABSTRACT Objective To evaluate the intra‐and interobserver reproducibility of the cervical elastography index (EI) measurements using strain elastography (SE) with a standardized acquisition protocol. Methods In this prospective cross‐sectional study, 301 women between 18 and 24...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...