Azienda Ospedaliero-Universitaria Cagliari

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

N-terminal proVGF modifications related to Amyotrophic Lateral Sclerosis

Objective: Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor dysfunction, for which effective therapies and early diagnostic biomarkers remain limited. This study comprehensively investigated ALS-associated alterations in the N...

Rt-PCR detection of West Nile virus in rhino-pharyngeal swabs in patients with neuroinvasive WNV: a preliminary experience

Abstract West Nile virus (WNV) diagnosis relies on serology and/or RNA detection in serum or cerebrospinal fluid (CSF). However, lumbar puncture may be contraindicated in some patients, and serological diagnosis can be limited by impaired antibody responses or persistent IgM posi...