Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo

Lung Ultrasound in Rheumatoid Arthritis–Associated Interstitial Lung Disease: Association with Radiological Patterns, Lung Function Tests, and Disease Activity—A Single-Center Retrospective Cross-Sectional Study

Introduction: Interstitial lung disease (ILD) represents one of the most relevant extra-articular manifestations in rheumatoid arthritis (RA), and significantly contributes to morbidity and mortality. High-resolution computed tomography (HRCT) is the gold standard for the diagnos...

PAD as a Marker of Systemic Atherosclerosis: A Comprehensive Review of Residual Risk and Contemporary Strategies for MACE and MALE Reduction

Background: Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis associated with substantial risks of major adverse cardiovascular events (MACE) and major adverse limb events (MALE). Scope: This comprehensive review examines the epidemiological and patho...

Real-world effectiveness and drug retention rate of risankizumab in patients with psoriatic arthritis: data from the multicentre GIRRCS cohort

Introduction Psoriatic arthritis (PsA) is a chronic heterogenous inflammatory disease characterized by a multidomain burden. Risankizumab, a selective inhibitor of the IL-23 p19 subunit, has shown efficacy in randomized trials; however, real-world data in PsA remain limited. We e...

The Impact of Metabolic and Bariatric Surgery on Nutritional Status and Sarcopenia: A Narrative Overview of Underlying Mechanisms, Clinical Implications, and Prevention Strategies

Bariatric surgery is the most effective treatment for severe obesity, leading to significant and sustained weight loss and improvement in metabolic comorbidities. However, it is also associated with substantial changes in body composition and nutritional status, including the ris...

Toward harmonized reporting of Alzheimer’s disease biomarkers in clinical practice

Abstract Cerebrospinal fluid biomarkers, and more recently blood-based biomarkers, are playing a pivotal role in reshaping the clinical management of neurodegenerative diseases, supporting early detection, biological diagnosis, patient stratification, prognostic assessment, thera...

Scientific Clinical Trial Publication Productivity in Medical Oncology: A Comparative Analysis and Data Review of Northern and Southern Italy

Background: Italy exhibits a socioeconomic divide between its northern and southern regions, which extends into healthcare delivery and biomedical research. Medical oncology is particularly affected by this structural imbalance. This paper examines geographic disparities in clini...

Factors associated with sleep disturbances in nursing students at the University of Palermo

<title>Abstract</title> <bold>Introduction</bold> : sleep disorders are very common among university students and can have negative effects on physical and mental health and academic performance. There is a close correlation between sleep disorders and psychological and behaviour...

Expiratory phase lung mechanics in late-onset Pompe disease: a multicenter study using oscillometry to identify specific breathing abnormalities

Abstract Introduction In late-onset Pompe disease (LOPD), muscle weakness causes restrictive lung impairment. In murine models, glycogen deposition in lung parenchyma suggests additional causes for restriction that remain poorly understood. We investigated whether oscillometry de...