Azienda Ospedaliera Sant'Andrea

Safety and Efficacy of Acute Normovolemic Hemodilution in Female Patients

Importance Female patients undergoing cardiac surgery have a higher transfusion burden, yet they remain underrepresented in randomized clinical trials. Although the ANH trial showed no significant reduction in the proportion of patients receiving allogeneic blood transfusions wit...

Preliminary evidence of long‐term safety and effectiveness of anti‐ CGRP drugs for migraine prevention in people with comorbid epilepsy: A 52‐week follow‐up retrospective study

Abstract Migraine and epilepsy frequently coexist, but evidence on the safety of calcitonin gene‐related peptide (CGRP)‐targeting therapies in people with epilepsy is lacking. We evaluated long‐term migraine and epilepsy outcomes in a real‐world multicenter retrospective cohort o...

Surgical treatment of complex scapular fractures: a single centre prospective observational study

Abstract Background Conservative management is traditionally preferred for scapular fractures, but recent studies suggest that surgical intervention may improve outcomes in selected patients. This study evaluates functional and imaging outcomes, complication rates, and under-repo...

Football Cleats and Injury Patterns in 14- to 19-Year-Old Female Football Players: The Effect of Surface, Gender-Specific Shoe Gear and Cleat Pattern

BACKGROUND: Female football (soccer) players are at increased risk for lower extremity injuries, yet prevention strategies remain based mostly on male athlete data. Modifiable extrinsic factors including footwear design and playing surface have not been well defined in youth fema...

Genetic and Molecular Determinants of Cancer Therapy-Related Cardiovascular Toxicity

Cancer therapy-related cardiovascular toxicity (CTR-CVT) is an umbrella term for myocardial, vascular, electrical, and inflammatory complications of cytotoxic, targeted, immune, and radiation-based therapies. Cancer therapy-related cardiac dysfunction (CTRCD) is used here more na...

Environmental Sustainability-Related Knowledge, Behaviors, and Perceived Barriers Among Italian Intensive Care Unit Nurses: A Cross-Sectional Survey

Background/Objectives: Healthcare systems are increasingly recognized as contributors to climate change, and intensive care units represent particularly resource-intensive clinical environments. Nurses play a central role in shaping daily care practices that may influence the env...

Association Between Proton Pump Inhibitor Use and Gastric Neuroendocrine Neoplasms in Autoimmune Gastritis: A Real‐World Propensity Score‐Matched Study From the Autoimmune gastRitis Italian netwOrk Study grOup

ABSTRACT Background and Aims Autoimmune gastritis (AIG) is characterized by chronic hypergastrinemia and is associated with an increased risk of gastric neuroendocrine neoplasms (gNENs). Because proton pump inhibitors (PPIs) further increase gastrin secretion, concerns have been...

Lean Mass Reduction During Glucagon-like Peptide-1 Receptor Agonists-Induced Weight Loss: Rethinking Its Clinical Significance

The substantial weight loss achieved with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual incretin agonists has transformed the management of obesity and cardiometabolic risk. However, the accompanying reduction in lean mass has raised concerns regarding potential...

Updating the Prevalence of H. pylori and Extensive Precancerous Lesions in the Stomach: Results of a Multicenter, Endoscopic Study

Background/Objectives: H. pylori is the main preventable risk factor for gastric cancer through the development of extensive precancerous lesions, namely mucosal atrophy and intestinal metaplasia. Methods: This multicenter, nationwide study enrolled consecutive patients who under...

Clinical outcomes of bleomycin electrosclerotherapy (BEST) for the treatment of slow-flow vascular malformations (SFVMs): a UK single-centre experience

BACKGROUND: Bleomycin Electrosclerotherapy (BEST) is an emerging treatment for slow-flow vascular malformations (SFVMs), utilising electroporation to enhance intralesional bleomycin uptake. This study evaluates the safety and clinical outcomes of BEST in reducing symptom severity...

Is robotic colorectal surgery worth the cost? An umbrella review integrating clinical outcomes, learning curve, and economic evidence

Robotic technology has progressively expanded within colorectal surgery owing to its enhanced instrument articulation and superior operative visualization. Despite these technical benefits, its adoption remains constrained by concerns regarding acquisition and procedural costs. F...

Preventive Strategies for Driveline Infections in Ventricular Assist Devices: A Systematic Review

Driveline infection (DLI) is the most frequent infectious complication in patients supported with ventricular assist devices (VADs) and remains a major cause of morbidity and rehospitalization. This systematic review aimed to synthesize the available evidence on preventive strate...