Azerbaijan Medical University

Multistep synthesis of novel indole–benzimidazole hydrazone hybrids as xanthine oxidase inhibitors: In-Vitro evaluation, molecular docking, MD simulations and DFT studies

This work reports the synthesis of a focused library of indole-benzimidazole hydrazone hybrids ( 17 - 35 ) via a multistep procedure involving thiolation, hydrazination, and Schiff base condensation. The final structures were confirmed using 1 H-NMR, 13 C-NMR, and FT-IR spectrosc...

Multi-Year Characterisation of Drought Adaptation and Grain Quality in Synthetic Hexaploid Wheat Genotypes

This study was conducted to evaluate yield components, biochemical traits, and drought tolerance in 66 synthetic hexaploid wheat (SHW) genotypes and standard cultivar Karahan. The experiment was conducted over three growing seasons at the Absheron Scientific Research Base of the...

TOPICAL BACTERIAL LYSATES IN CHILDREN WITH ADENOID HYPERTROPHY AND CHRONIC ADENOIDITIS

Adenoid hypertrophy and chronic adenoiditis are common disorders in childhood and may contribute to persistent nasal obstruction, recurrent respiratory infections, sleep-disordered breathing, and middle-ear disease. This study evaluated the effectiveness of topical bacterial lysa...

Exogenous ATP Attenuates Biochemical and Histological Markers of Osimertinib-Associated Myocardial Injury in Rats

(1) Background: Osimertinib is an effective third-generation EGFR tyrosine kinase inhibitor, but its clinical use may be limited by cardiotoxicity. This study investigated the relationship between reduced measured cardiac ATP levels and osimertinib-associated cardiac injury and e...

Protective effects of flunarizine and ATP against pembrolizumab-associated gastric injury in rats

Abstract Pembrolizumab, an immune checkpoint inhibitor targeting pro-grammed cell death protein-1 (PD-1), is widely used in cancer therapy. However, its potential gastrotoxic effects and underlying molecular mechanisms remain poorly understood. Flunarizine has antioxidant, calciu...

Transmission Electron Microscopy–Based Analysis of Silver Nanoparticle–Induced Ultrastructural Damage and Bioaccumulation in Heterakis dispar (Nematoda: Heterakidae) Under In vitro Conditions

Helminths cause a wide range of diseases in different components of ecosystems and may induce serious pathological conditions in the host organisms. In recent years, nanoparticles have been increasingly used in ecology, veterinary medicine, and biology. In this study, the effect...

Morphology-Based Surgery for Chronic Pancreatitis Across Europe: Toward the Next Generation of Unified Guidelines

OBJECTIVE: To evaluate the use and impact of current surgical guidelines for chronic pancreatitis (CP) across Europe. SUMMARY BACKGROUND DATA: Current guidelines recommend morphology-based surgery for CP, but international studies evaluating their use and impact are lacking. METH...

Inorganic hole-transport layer engineering for high-efficiency Mg2Mn3O8 solar cells: a multiphysics simulation study

Abstract We carry out a comprehensive numerical investigation to evaluate the influence of various hole transport layers (HTLs) on the performance of FTO/TiO 2 /Mg 2 Mn 3 O 8 /HTL/Ag solar cells. Five HTLs, PEDOT:PSS, P3HT, Spiro-OMeTAD, Cu 2 O, and MoO 3 , were examined through...

Investigation of the Semiconductor Properties and Chronoamperometry of BI2SE3 Thin Films Obtained by Electrochemical Deposition

Thin Bi2Se3 films were successfully electrodeposited from a non-aqueous ethylene glycol-based electrolyte and subsequently underwent thermal treatment in an Ar atmosphere to improve crystallinity. The phase and compositional properties of the films were characterized by X-ray dif...

Does Government Environmental Spending Crowd in Green Investment? The Role of Carbon Pricing and the Limits of Fiscal Policy Alone

Governments around the world are spending more on environmental protection, but it is far from obvious that this spending pulls private capital into green assets. This paper asks whether government environmental expenditure crowds in green investment at the country level, whether...