Avon and Wiltshire Mental Health Partnership NHS Trust

Risk of orofacial clefts in offspring following maternal exposure to anti-seizure medications in a UK CPRD GOLD observational study

Abstract Orofacial clefts (OFC) are complex congenital anomalies characterised by a gap in the upper lip and/or palate, causing speech and feeding difficulties in children. Studies suggest inconsistent findings for an association between anti-seizure medications (ASM) and OFCs. O...

Do participant testimony videos make people more interested in taking part in a clinical trial? A randomised Study Within a Trial (SWAT), registration SWAT203

Abstract Background Potentially eligible participants do not always agree to take part in trials when approached, which makes recruitment more challenging, time-consuming, and costly. We conducted a Study Within a Trial (SWAT) to evaluate whether showing people brief video testim...

Genetic risk factors for postoperative complications after major surgery and shared genetic aetiology with non-postoperative phenotypes

Abstract Background Up to 15% of patients worldwide experience serious postoperative complications after major surgery. We explored the genetic basis of five common postoperative complications and whether they share genetic aetiology with their non-postoperative equivalents. Meth...

Psychological safety, anxiety and professional identity among UK surgical physician associates

Abstract Background Physician Associates (PAs) are increasingly embedded within UK surgical teams, yet little is known about their psychological safety, occupational wellbeing, risk orientation, exposure to online hostility, or career aspirations. Surgical PAs represent a small s...

Sleep as a window into thalamocortical pathology: generative modeling implicates NMDA receptor hypofunction in 22q11.2 deletion syndrome

Abstract 22q11.2 deletion syndrome (22q11.2DS) is a strong genetic risk factor for neuropsychiatric conditions, including schizophrenia, yet the underlying synaptic mechanisms remain unclear. Sleep EEG suggests thalamocortical dysfunction, but scalp data alone lack mechanistic re...

Antidepressant Prescribing Trends for Adults With and Without Autism in the United Kingdom From 1997 to 2023: A Population‐Based Cohort Study Using Clinical Practice Research Datalink Aurum

Antidepressant prescribing and autism diagnoses have increased in recent years. We aimed to describe and compare trends in antidepressant prescribing, indications, doses and durations in autistic and non-autistic males and females in the United Kingdom (UK) from 1997 to 2023. Usi...

The Mother Nature Programme: a single-arm mixed-methods feasibility study of a group nature-based intervention for mothers experiencing postnatal mental health difficulties and their infants

Abstract Background Postnatal mental health difficulties are common and often under-treated. Nature-based interventions have potential mental health benefits, but little research has focussed on their applicability postnatally. This study examined the acceptability and feasibilit...