Austrian Cluster for Tissue Regeneration

Disentangling the role of adaptive immunity in Alzheimer’s disease

Abstract Alzheimer’s disease (AD), the most common age-related neurodegenerative disorder, is characterized by progressive synaptic and neuronal loss, amyloid-β deposition, hyperphosphorylated tau accumulation, and chronic neuroinflammation, traditionally attributed primarily to...

Keratinocytes with DNA Aberration Induced by UVB Become Susceptible to Ferroptosis

Keratinocytes are key epidermal cells that are highly susceptible to ultraviolet (UV)-induced damage, which can lead to DNA mutations and the development of malignancies. In parallel, UV radiation induces lipid peroxidation (LPO), potentially facilitating the activation of ferrop...