Austrian Centre of Industrial Biotechnology (Austria)

Dual‐Function Cosubstrates Enable Threonine Dehydrogenase‐Driven Chemoenzymatic Pyrrole Synthesis

ABSTRACT Preparative biocatalytic synthesis of substituted pyrroles remains challenging despite recent advances in enzymatic α‐aminoketone generation. In this study, we report a concurrent chemoenzymatic cascade to disubstituted pyrroles based on threonine dehydrogenase (ThrDH)‐c...