Australian National Fabrication Facility

Fenestrated Microneedle Biosensor for Continuous In Vivo Lactate Monitoring in Interstitial Fluid

ABSTRACT Lactate is a key biomarker of tissue metabolism and oxygenation, yet clinical assessment still relies on intermittent blood tests that overlook rapid metabolic dynamics and disrupt clinical workflows. Continuous transdermal monitoring of lactate in interstitial fluid (IS...

Transferrin-Conjugated Polymeric Nanoparticles via Polymerization-Induced Self-Assembly for Enhanced BBB Transport and Glioblastoma Therapy

Abstract Transferrin-coated nanoparticles show promise in delivering chemotherapeutic drugs across biological barriers for treating glioblastoma multiforme (GBM). Employing a synthetic approach integrating advanced chemistries and bespoke in vitro biological assays, we developed...