Austin Hospital

An Exploratory Study of ABT-806, a Tumor-Specific Anti-EGFR Antibody, in Subjects with Recurrent or Metastatic Head and Neck and Other Squamous Cell Carcinomas

Introduction: Despite their benefit, current anti-EGFR therapies are limited by narrow efficacy profiles due to dose-limiting toxicities. This phase 2 open-label study evaluated the efficacy and safety of ABT-806, an EGFR-targeting antibody that is tumor specific, in patients wit...

Management of De Novo miN1 Prostate Cancer in the PSMA-PET Era.

BACKGROUND: Prostate-specific membrane antigen positron emission tomography (PSMA-PET) is reshaping nodal staging in prostate cancer by detecting regional lymph node metastases with greater accuracy than conventional imaging. This has created a new cohort of patients with N1M0 di...

The feasibility of a tailored follow-up service for people living with stroke via a registry-based randomised controlled trial (A-LISTS)

After stroke, people report ongoing health challenges to national registries without any follow-up. We aimed to assess the feasibility of a co-designed, registry-initiated, follow-up service provided by hospitals and tailored for people reporting health-related challenges between...

Seizure control and foetal malformation in primiparous women with Epilepsy: statistical analysis of data from a prospective observational study

Purpose To evaluate seizure control and foetal malformation in the first pregnancy of women with epilepsy through the analysis of the Australian Pregnancy Register database focusing of women with epilepsy intending or beginning their first pregnancy. This was achieved through a s...

Long-term outcomes of out-of-hospital cardiac arrest survivors in New Zealand: A prospective, longitudinal cohort study

Objective Out-of-hospital cardiac arrest (OHCA) is a devastating event that can have ongoing neurological and functional sequelae for survivors, which impact their whānau/family and society. Information on long-term survival remains incomplete. We aimed to understand the long-ter...

Ketamine for Analgosedation in Mechanically Ventilated Adults: A Double-Blind Randomized Trial

OBJECTIVES: The role of ketamine for analgosedation in the ICU remains unclear. This study aimed to assess the efficacy of low-dose ketamine infusion for adjunct analgosedation in adults receiving mechanical ventilation. DESIGN: A prospective, double blind, randomized, placebo-co...

Muscle size matters: making paediatric vaccination safe for all - a pilot study

Background/objectives Shoulder Injury Related to Vaccine Administration (SIRVA) is an uncommon but clinically significant iatrogenic complication of vaccination, associated with improper injection depth or site selection. This pilot study aimed to evaluate the suitability of exis...

The effect of augmented protein intake on nitrogen balance: A nested cohort study of the TARGET protein trial

Purpose The impact of augmenting enteral protein delivery on nitrogen balance, urea generation, and kidney function in critically ill patients remains poorly defined. This study aimed to investigate these effects in a nested cohort within the TARGET Protein trial. Methods We cond...

P1.169. Magnetic and ICG High Risk Lymph Node Mapping in Upper GI Cancer: A Safety, Feasibility and Diagnostic Performance Clinical Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Accurate localisation of high-risk lymph node (HRLN) stations in upper gastrointestinal cancer could enable tailored resection and focused ultra-staging while avoiding unnecessary lymphadenectomy...

Association between prior ICU admission for drug overdose and ICU readmission: A retrospective registry-based study

Objective We aimed to investigate patients discharged alive from hospital following an ICU admission for drug overdose and whether exposure of prior overdose-related ICU admission was associated with a future ICU readmission. Design, setting, participants This multicentre registr...

Hypothermia in the intensive care unit after surgery: a registry based retrospective cohort study

Background Hypothermia is common in patients admitted to the ICU after surgery; however, its relationship with postoperative outcomes has not been fully explored. This study investigates the association between postoperative hypothermia in the ICU and patient mortality. Methods R...

Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective

ABSTRACT Primary biliary cholangitis (PBC) is an autoimmune liver disease that targets the small intrahepatic bile ducts with diagnosis based on elevated serum alkaline phosphatase (ALP) levels and the presence of anti‐mitochondrial antibodies. Untreated, it may run a progressive...