Institution
AstraZeneca (Spain)
Recent research
- Health & Medicine
Initial Changes in eGFR during Treatment with Balcinrenone and Dapagliflozin
Introduction: The novel non-steroidal mineralocorticoid receptor antagonist balcinrenone in combination with dapagliflozin reduced urinary albumin-to-creatinine ratio (UACR) over 12 weeks in the MIRO-CKD phase 2 trial in chronic kidney disease (CKD) and induced a modest acute eGF...
- Health & Medicine
Tozorakimab to Prevent COPD Exacerbations
BACKGROUND: Many patients with chronic obstructive pulmonary disease (COPD) have exacerbations despite receiving standard-of-care inhaled maintenance therapy. Dysregulated interleukin-33 signaling is implicated in the pathogenesis of COPD. Tozorakimab is a monoclonal antibody tha...
- Health & MedicineOpen access
The rapid evolution of SARS-CoV-2 has necessitated efforts to accelerate the clinical evaluation of neutralizing monoclonal antibodies. Little DIPPER and the SUPERNOVA substudy explored the feasibility of immunobridging efficacy from tixagevimab–cilgavimab to sipavibart using pre...
- AI & ComputingOpen access
Regulator constants and cohomology
Abstract We show how regulator constants of a finitely generated ‐module can be related to ‐cohomology, where is a finite group. We then derive consequences of this relation for modules naturally arising in number theory, such as rings of integers and units of number fields, ‐the...