Institution
AstraZeneca (Singapore)
Recent research
- BiologyOpen access
Proteome-guided drug discovery maps and mitigates therapeutic degrader toxicity
Abstract Heterobifunctional targeted degraders (HBDs) enable potent removal of protein targets but their clinical success can be hindered by de novo toxicity inherent to their bivalent chemistry. Here we introduce a drug discovery framework that exploits high-throughput proteomic...
- Health & MedicineOpen access
Abstract Herein, we report a transition metal-free synthesis of monofluoroalkenes via a C–F bond reconstruction approach. The process employs inexpensive BF3·Et2O as a catalyst for the stereoselective intermolecular fluoroacylation of unactivated alkynes with alkyl/aryl acid fluo...
- BiologyOpen access
Next‐Generation Manufacturing: The Evolving Role of Biocatalysis in AstraZeneca
Biocatalysis is becoming a strategic manufacturing capability at AstraZeneca, enabling selective transformations under milder conditions and with the potential to reduce waste and resource intensity relative to conventional routes. This review summarizes how AstraZeneca is embedd...
- Health & Medicine
Tozorakimab to Prevent COPD Exacerbations
BACKGROUND: Many patients with chronic obstructive pulmonary disease (COPD) have exacerbations despite receiving standard-of-care inhaled maintenance therapy. Dysregulated interleukin-33 signaling is implicated in the pathogenesis of COPD. Tozorakimab is a monoclonal antibody tha...
- Materials & EnergyOpen access
Abstract Deep eutectic solvents (DESs) are emerging sustainable alternatives to traditional organic solvents, yet their influence on chemical reactivity remains underexplored. Here, we investigate the oxidation of aldehydes to carboxylic acids using diluted hydrogen peroxide in a...