AstraZeneca (Brazil)

The RobinCar Family: R tools for robust covariate adjustment in randomized clinical trials

Abstract Purpose Covariate adjustment is a powerful statistical technique that can increase efficiency in clinical trials. Recent guidance from the U.S. Food and Drug Association (FDA) provided recommendations and best practices for using covariate adjustment. However, there has...

SurvSurf: a partially monotonic neural network for first-hitting time prediction of intermittently observed discrete and continuous sequential events

Abstract We propose SurvSurf, a neural-network-based survival model for direct, simultaneous probabilistic prediction of first-hitting times of sequential events from baseline. Unlike existing models, SurvSurf is theoretically guaranteed to never violate the monotonic relationshi...