AstraZeneca (Australia)

A Hybrid Mechanistic Model Capturing Lactate Run‐Away and Back‐Metabolism in Mammalian Cell Culture

ABSTRACT Mechanistic modeling is important in biopharmaceutical manufacturing by enabling in‐silico experimentation. However, developing a robust mechanistic model for mammalian cell culture remains challenging due to the complexity of the underlying bioprocesses. Existing data‐d...

Treatment patterns and outcomes in US patients with unresectable HCC treated with embolization

Aims To describe treatment patterns and outcomes in patients with unresectable hepatocellular carcinoma (uHCC) treated with embolization.Materials & methods This retrospective observational study used Optum’s de-identified Market Clarity Data. US adults with HCC treated with embo...

Monoclonal Antibody Coformulations Reveal Three Interaction Patterns Governing Stability

Abstract Coformulated monoclonal antibodies (mAbs) offer a promising next-generation therapeutic strategy by combining multiple antibodies in a single drug product to enhance efficacy and improve patient compliance. However, ensuring the quality and stability of individual compon...

Fundamental dynamical units for physics-informed structural inference from perturbation time-series in networked systems

Abstract In networked dynamical systems, the parameter of primary mechanistic interest is signed interaction structure. Recovering this structure from perturbation time-series data is a fundamental identification problem, compounded by three coupled obstacles: the combinatorial c...

Radical Disconnection Logic Enables Direct Conversion of α-Amino Acids into Differentiated Vicinal Diamines

Abstract Functional group interconversions (FGIs) are foundational to synthesis, yet classical acid-to-aminomethyl transformations remain intrinsically step- and redox-intensive. Here we introduce a radical disconnection strategy that enables the direct conversion of α-amino acid...

Leveraging neural network models for drug repurposing: a case study on cardiac hypertrophy

Abstract Drug repurposing has emerged as an attractive strategy in contemporary pharmaceutical research, presenting an opportunity to expedite drug discovery, minimize developmental costs, and mitigate risks associated with developing new pharmaceuticals. In this study, we invest...

Tozorakimab to Prevent COPD Exacerbations

BACKGROUND: Many patients with chronic obstructive pulmonary disease (COPD) have exacerbations despite receiving standard-of-care inhaled maintenance therapy. Dysregulated interleukin-33 signaling is implicated in the pathogenesis of COPD. Tozorakimab is a monoclonal antibody tha...

Safety, Pharmacokinetics, and Predicted Neutralizing Activity of the SARS-CoV-2 Monoclonal Antibody Sipavibart: Results from Little DIPPER and the SUPERNOVA Substudy

The rapid evolution of SARS-CoV-2 has necessitated efforts to accelerate the clinical evaluation of neutralizing monoclonal antibodies. Little DIPPER and the SUPERNOVA substudy explored the feasibility of immunobridging efficacy from tixagevimab–cilgavimab to sipavibart using pre...