ASST Fatebenefratelli Sacco

Transoral robotic versus laser surgery for cT1-T3 supraglottic laryngeal cancers: a systematic review and meta-analysis of comparative and non-comparative studies

Background To compare literature findings about functional, oncological and surgical outcomes of transoral robotic (TORS) versus transoral laser microsurgery (TOLM) for supraglottic cT1-T3 laryngeal cancers. Methods Three independent investigators conducted a PubMed, Scopus, and...

ADHD Presentations and Severity in Adults: Psychometric Profiles, Psychiatric Comorbidities, and Emotional Dysregulation in Relation to Psychiatric Hospitalization

Background/Objectives: Attention-deficit/hyperactivity disorder (ADHD) in adults is heterogeneous in symptom presentation, severity, and comorbid psychopathology, yet systematic data from Italian clinical populations remain limited. Methods: In this retrospective, cross-sectional...

Explantation rates and failure mechanisms in early cannulation grafts: A comparative study between Flixene and Gore Acuseal

Background: Early cannulation arteriovenous grafts (ecAVGs) are increasingly used to reduce catheter dependence in hemodialysis patients, but device-specific complications remain a concern. This study aimed to compare explantation rates, timing, and mechanisms of failure between...

Beyond Genotype: Integrating Phenoconversion into Pharmacogenetic Decision-Making in Psychiatry

Interindividual variability in psychotropic drug response contributes to treatment failure, adverse drug reactions, and repeated medication adjustments. Pharmacogenetics supports precision prescribing by identifying genetic variants associated with drug metabolism, efficacy, and...

Economic evaluation of standard versus integrated short peripheral catheters

BACKGROUND: Integrated short peripheral catheters (ISPCs) have been developed to reduce the risk of catheter failure compared with traditional short peripheral catheters (SPCs). Although clinical benefits have been demonstrated in randomized studies, economic evidence remains inc...

Automated B-lines quantification with lung ultrasound in mechanically ventilated patients

BACKGROUND: If ultrasound dedicated software for the identification and quantification of interstitial syndrome is equal or superior to experts observation is still being explored. The primary objective of this study was to compare the performance of an automatic method based on...

Pharmaceutical 3D Printing From Personalized Medicine to Super-Compounding Pharmacies: A Narrative Review

Objectives: This narrative review explores how pharmaceutical 3-dimensional printing (3DP) can transform solid dosage form manufacturing from industrial mass production to truly personalized medicine, particularly for vulnerable cohorts such as pediatric, geriatric, and rare dise...

Non– AIDS ‐Defining Cancer Incidence in People With HIV in Milan, Italy, 2000–2023: Temporal Trends and Comparison With the General Population

People with HIV (PWH) are living longer, but contemporary data on non-AIDS-defining cancers (NADCs) in Italy remain limited. We assessed incident cancers in a retrospective cohort of PWH in Milan, Italy, between January 2000 and December 2023. Follow-up was grouped into 2000-2007...