Asia University

Design and Experimental Validation of an Embedded Edge Artificial Intelligence Camera System for Real-Time Intelligent Vision

This study presents the design and experimental validation of an embedded edge artificial intelligence (AI) camera system for intelligent vision applications. The developed system integrates a multicore edge computing processor and a dedicated AI engine into a compact smart camer...

Progressive Conduction System Disease Preceding Hypertrophy in IVS4 + 919G > A Fabry Variant: a Population-based Electrocardiographic Study

BACKGROUND: The IVS4 + 919G > A variant is the most prevalent late-onset Fabry variant in East Asian populations, but its electrophysiological trajectory remains incompletely defined. METHODS: From a regional genetic screening program, 905 IVS4 + 919G > A carriers were identified...

Treatment-Free Interval as a Prognostic Factor for Survival Outcomes in Patients with Advanced or Recurrent Endometrial Cancer Treated with Pembrolizumab Plus Lenvatinib: A Multi-Institutional Real-World Cohort Study

Background/Objectives: The treatment-free interval (TFI) predicts benefit from platinum rechallenge in gynecological cancers, but its prognostic value in patients receiving second-line pembrolizumab plus lenvatinib for recurrent endometrial cancer (EC) is unknown. We evaluated wh...

Frontline bevacizumab in ovarian clear cell versus high-grade serous ovarian cancer: survival outcomes and recurrence patterns in a real-world cohort

Ovarian clear cell carcinoma (OCCC) is associated with inferior survival compared to high-grade serous ovarian cancer (HGSOC), largely due to its relative chemoresistance and near-universal BRCA wild-type status. Whether frontline bevacizumab can mitigate this survival disadvanta...

Association of allergic rhinitis with polysomnographic arousal indices in children with sleep-disordered breathing

Abstract Background Children with allergic rhinitis (AR) frequently experience sleep disruption and have a higher prevalence of sleep-disordered breathing (SDB). However, the specific impact of AR on sleep architecture across different SDB subtypes, such as obstructive sleep apne...

Species-Dependent Citrus–Simvastatin Interaction Profiles in an Acute Rat Model: Integrating Drug Disposition, Hepatic Redox, and Complementary Computational Analysis

Abstract Citrus species differ widely in flavonoid chemistry, yet grapefruit has come to represent the genus in citrus–statin interactions. To test whether this translates into species-dependent interaction profiles, six flavonoid-profiled citrus peel extracts (Citrus limon, C. d...

Chinese herbal medicine therapy reduces all-cause and cardiovascular disease-related mortalities in acquired hemolytic anemia: A Taiwanese nationwide retrospective cohort study

Objectives To assess whether Chinese herbal medicine (CHM) treatment was associated with all-cause and cardiovascular disease (CVD)-related mortality in Taiwanese patients with acquired hemolytic anemia (AHA). Design & setting This population-based retrospective cohort analysis u...

Nonsurgical Platelet Membrane-Decorated Gold Yarnball Brain Antenna for In Situ Nitric Oxide Generation and Neuronal Regeneration

Bioelectronic implants for brain stimulation are widely used to treat neurological disorders and promote neuronal repair; however, their clinical application is limited by invasive surgical implantation. To address this challenge, here, platelet membrane-decorated gold yarnballs...

Campylobacter jejuni genotoxin promotes intestinal inflammation via the DNA damage-cGAS-STING signaling axis

The foodborne agent Campylobacter jejuni is a pervasive zoonotic pathogen and a major cause of gastrointestinal disease associated with inflammatory disorders in humans. While its genotoxin, cytolethal distending toxin (CDT), induces DNA damage, the toxicological signaling events...

Automated CT-Based Quantification of Pulmonary Fibrosis Using Deep Learning-Based Lung Segmentation

Background/Objectives: To develop and evaluate an automated CT-based framework for the quantitative assessment of fibrotic interstitial lung disease (ILD), including idiopathic pulmonary fibrosis (IPF), using a standardised six-level anatomical protocol and deep-learning lung seg...

Edge weight concentration overcomes node degree blindness in graph based network intrusion detection

Abstract Graph-based network intrusion detection almost universally represents attacker behavior through node-centric structural features – degree, centrality, embeddings from graph neural networks – which implicitly assume that an attacker's identity is visible as a distinct nod...

Effect of APOE and LPA genotypes on the risk of dementia after myocardial infarction: a clinic-based cohort study

Survivors of myocardial infarction (MI) face elevated risk of subsequent cognitive decline, yet the relative contributions of neurodegenerative susceptibility ( APOE4 ) and lipid-mediated vascular burden ( LPA risk variants) to post-MI dementia remain unclear, particularly in Asi...

Beyond Central Subfield Thickness: Early Multi-Slice Optical Coherence Tomography Structural Response After Faricimab Injection in Real-World Diabetic Macular Edema

Objectives: We sought to evaluate the early efficacy of faricimab (Vabysmo®) in treating diabetic macular edema (DME) and to explore the predictive value of multi-slice optical coherence tomography (OCT) biomarkers for anatomical and visual outcomes. Methods: In this retrospectiv...

Short Report: Divergent Sleep–Wake Regularity in U.S. Children With Autism Spectrum Disorder: Bedtime vs Wake-up Regularity

Sleep–wake regularity is an emerging dimension of sleep health, yet its association with autism spectrum disorder (ASD) remains understudied in nationally representative samples, particularly across distinct components of sleep timing. Using parent-reported data from 11,462 U.S....

Glycemic and Lipid Outcomes Associated with Bitter Melon Blood-Sugar-Modulating Protein and Metformin Use: A Translational Preclinical and Retrospective Study

Background/Objectives: Interactions between botanical supplements and standard antidiabetic therapies remain poorly understood. This study investigated the efficacy and mechanistic properties of a bitter melon blood-sugar-modulating protein (BMP) in relation to concurrent metform...

Associations between impaired intrinsic capacity and emergency room visits among community-dwelling older adults

Background Emergency room (ER) visits in older adults are associated with increased morbidity and mortality. The World Health Organization’s Integrated Care for Older People (ICOPE) framework assesses intrinsic capacity (IC), but the association between IC impairments and ER visi...

A Reproducible Evidence-Audit Framework for Leakage, Feature Stability, and Transportability in Translational Omics Classification

Submission-aligned code, outputs, figures, supplements, and manuscript for a reproducible evidence-audit framework in high-dimensional translational omics classification. A naive global-selection workflow is contrasted descriptively with a guarded nested workflow; because the arm...

A Novel Hemizygous CDX4 Missense Variant Identified in a Taiwanese Man with Severe Teratozoospermia

Background and Objectives: Male factors account for approximately 30–50% of subfertile couples. Teratozoospermia is one of the major causes of male infertility; however, the genetic factors underlying many cases remain incompletely understood. This study aimed to identify potenti...

Valuation, Profitability, and Subsequent Stock Returns: Firm Fixed-Effects Evidence from Taiwan

Abstract : This study examines whether valuation ratios and profitability are associated with subsequent-quarter stock returns in Taiwan. The analysis applies firm fixed-effects regressions with quarter fixed effects and firm-clustered standard errors. The results show that ROE i...

Martian‑Regolith Simulant Confined Nanogenerators for Wireless Tactile Sensing for Human‐Machine Interface

Achieving a sustainable energy system for space missions remains challenging due to the continued reliance on Earth-supplied materials. This underscores the importance of in situ resource utilization (ISRU) strategies that convert planetary resources into functional electronic co...