Aretaeio Hospital

Evaluating early systemic therapies in the neoadjuvant setting for the treatment of urological cancers

INTRODUCTION: Neoadjuvant systemic therapy represents an evolving cornerstone in the multidisciplinary management of urological malignancies. While cisplatin-based neoadjuvant chemotherapy historically represented the sole standard of care for muscle-invasive bladder cancer, nove...

Development and Preliminary Evaluation of a Questionnaire on Parental Informed Consent in Neonatal Research

Background: Advances in neonatology and paediatric pharmacology have markedly improved neonatal survival, particularly among preterm and critically ill infants. At the same time, clinical research constitutes the cornerstone for generation of evidence on the safety and efficacy o...

The Role of Clomiphene Citrate in Gonadotropin Stimulation Protocols in Poor Responders: A Mini-Review of Recent Clinical Evidence

Diminished ovarian reserve (DOR) and poor ovarian response (POR) remain among the most challenging conditions in assisted reproductive technology, and no optimal stimulation strategy has been established. Clomiphene citrate (CC), a selective estrogen receptor modulator that augme...

Histological manifestations of vitamin A toxicity in the liver

Vitamin A (VitA) is a fat-soluble micronutrient involved in various physiological processes. Its sustained intake exceeding physiological needs leads to increased hepatic accumulation warranting careful monitoring for potential health implications. Despite being widely studied in...

Safety and efficacy of delivering systemic treatments concomitantly with whole-brain radiotherapy: a prospective, observational, single-institution study

Aim: The aim of our study was to evaluate the safety and efficacy of delivering systemic treatments concurrently with whole-brain radiotherapy (WBRT). Methods: A single-institution, prospective observational study was conducted in Athens, Greece, including 99 patients treated wit...