Ardabil University of Medical Sciences

Early life stress caused glucose homeostasis impairment and anxiety-like behavior along with oxidative stress in adolescent male rat offspring: Protective effect of saffron extract

Early life stress (ELS) significantly contributes to metabolic and psychological disorders by triggering oxidative stress and disrupting the hypothalamic–pituitary–adrenal (HPA) axis. This research examined ELS effects on redox status, along with anxiety-like behavior, in adolesc...

Renal and hepatic injury markers trajectories and respiratory symptoms in iron ore processing plant workers

Abstract Mining is a high-risk occupation, with mineral dust exposure leading to various occupational diseases. This study aimed to assess respiratory symptoms and longitudinal changes in renal and hepatic injury markers among workers occupationally exposed to iron dust and cryst...

Retrospective Cohort Study of Tracheal Etiological Agents and their Drug Resistance in Patients Referred to Imam Khomeini Hospital in Ardabil City from 2012 to 2022

Background Endotracheal tube-associated infections, an important cause of mortality in patients admitted to Intensive Care Units (ICU), are mainly caused by opportunistic, Multidrug-Resistant (MDR) bacteria. Accurate diagnosis of etiological agents and investigation of their anti...

Prevalence of vancomycin- and aminoglycoside-resistant pathogenic enterococci in municipal wastewater: A study in northwest Iran

ABSTRACT The extensive use of antimicrobials has contributed to the emergence of multidrug-resistant (MDR) microorganisms in municipal wastewater. The prevalence, resistance patterns, and virulence factors of Enterococcus species were studied in 25 untreated municipal wastewater...

Genetically engineered dendritic cells in cancer immunotherapy: from immune reprogramming strategies to emerging CAR-DC platforms

Genetic engineering can enhance dendritic cell (DC) migration, antigen presentation, co-stimulation, cytokine production, survival, and resistance to tumor-mediated suppression. This review examines established engineering strategies and emerging chimeric antigen receptor-enginee...

Advances in regenerative medicine and their impact on cancer therapy and tumor microenvironment modulation

Regenerative medicine has emerged as a transformative field that can augment cancer therapy by leveraging stem cells, gene therapy, and tissue engineering to address limitations of conventional treatments. This review synthesizes recent advances in cell-based therapies, biomateri...

Chemotherapy and male fertility: genotoxic effects on sperm DNA and germ cell integrity

Infertility is a serious concern for young male patients of reproductive age undergoing chemotherapy, which commonly disrupts fertility either temporarily or permanently. Cytotoxic chemotherapeutic agents primarily target rapidly dividing cells; consequently, male germ cells, whi...

Chronic traumatic popliteal arteriovenous fistula presenting twenty years after shotgun injury: a case report and critical literature review

Traumatic arteriovenous fistulas (AVFs) account for only 2.5–4% of penetrating vascular injuries, yet their natural history is insidious: most remain hemodynamically compensated for years before clinical decompensation. Delayed popliteal AVF poses unique diagnostic and therapeuti...

A qualitative evaluation of dengue surveillance system implementation in southern Iran following autochthonous transmission

Dengue fever, a re-emerging mosquito-borne viral disease, poses an escalating global health threat exacerbated by climate change and globalization. While Iran has historically reported only imported dengue cases, autochthonous transmission has been documented in southern province...

Climate change and cardiovascular diseases: a review of systemic challenges, policies, and management strategies

Climate change threatens cardiovascular health, yet health-system responses remain underexamined. This scoping review maps pathways linking climate change to cardiovascular diseases (CVDs), identifies health-system challenges, and synthesises global, regional, and national polici...

Are oral hygiene behaviors associated with lower stroke risk? A systematic review

This study aims to systematically synthesize observational evidence on the association between oral hygiene behaviors, including tooth brushing, interdental cleaning, dental visits, and professional dental cleaning, and stroke risk in adults. A PRISMA-compliant systematic review...

Lateral violence and its relationship with intention to quit among emergency department nurses at Ardabil Medical Training Centers

Abstract Purpose Lateral violence among nurses is a critical workplace issue that threatens nurse well-being, patient safety, and staff retention. This study aimed to examine the prevalence of lateral violence and its relationship with intention to quit among emergency department...