Arctic Research Centre

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

ABSTRACT CEP55, a centrosomal protein frequently overexpressed in multiple cancers, is implicated in regulation of genomic instability and PI3K/AKT pathway activation, yet its role in tumor progression and the tumor microenvironment remains incompletely defined. Here, we develope...

Continuous sampling of cerebrospinal fluid from the 3rd ventricle of the hypothalamus to identify accumulating or depleting metabolites during hibernation

Hibernation is a seasonally regulated process dramatically reducing metabolic rate and subsequently core body temperature (Tb). Many hibernators repeatedly cycle between torpor and arousal (T-A cycling) throughout the hibernation season. How these cycles are regulated is still un...