ARC Centre of Excellence for Innovations in Peptide and Protein Science

A diversified approach to the design of recombinant silk proteins for biomaterials

Silk offers a sustainable alternative to synthetic polymers, yet widespread industrial adoption has not been realised. Many current silk protein engineering efforts have focused on spider dragline silk; a pursuit made difficult by the metabolic burden of expressing high molecular...

Specific targeting of MR1-antigen complexes using nanobodies

T cell receptor mimic (TCRm) antibodies that bind peptide–human leukocyte antigen complexes have great therapeutic potential. Major histocompatibility complex class I–related protein 1 (MR1) exhibits limited polymorphism and presents conserved metabolites, such as 5-OP-RU, derive...

Synthesis of Glycopeptide Antibiotic Peptide Substrates Using Knorr‐Pyrazole Chemistry

The glycopeptide antibiotics (GPAs) remain clinical antibiotics used against drug‐resistant Gram‐positive infections. The discovery of GPAs continues, with new type IIa and V GPAs, the kineomicins, the rimomycins, and corbomycin, being recently identified. Despite this larger rep...

Structure-guided allosteric modulation of the delta opioid receptor

Abstract Opioid analgesics remain essential for pain management but are associated with significant adverse effects, including respiratory depression, tolerance, and dependence. The δ-opioid receptor (δOR) represents a promising therapeutic target for developing safer opioid anal...

Assessing Vancomycin‐Formyl Peptide Conjugate Binding to the Surface of Resistant Staphylococcus aureus via Flow Cytometry

Staphylococcus aureus strains have emerged with resistance mechanisms that reduce the efficacy of last resort antibiotics and evade the immune system. One strategy to combat antimicrobial resistance is to modulate host immunity to eliminate infections more effectively. This has l...