Applied Nanotech (United States)

A Two-Step Synthesis of Covalent Genetically Encoded Libraries of Peptide-Derived Macrocycles Enables the Use of Electrophiles with Diverse Reactivity

Abstract Genetically encoded libraries of peptide-derived macrocycles containing electrophile “warheads” (cGELs) can be used to identify potent and selective covalent ligands for protein targets. Such cGELs are synthesized either by incorporation of unnatural amino acids that dis...

Built-in electric field leverages synergistic thermodynamic–kinetic enhancement for superior fixed-bed oxyanion adsorption

Fixed-bed adsorption is a widely adopted method for the removal of diverse aqueous pollutants at the industrial scale, including oxyanions such as arsenite [As(III)], arsenate [As(V)], and phosphate [P(V)]. However, owing to the inherently unsteady operating conditions, effective...