AO Foundation

Multi‐Scale 3D Printing of Magnetic Polymer Nanocomposites with Controlled Particle Dispersion and Hyperthermic Response

ABSTRACT The ability to encode well‐defined physical properties and spatiotemporally controlled responses into multifunctional nanocomposites is enabling a new generation of advanced responsive systems. We describe the synthesis of magnetic nanoflowers (NFs) and their full disper...

Mechanical Loading Reshapes Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicle microRNA Cargo Toward Predicted Immunomodulatory and EV Cargo-Trafficking Pathways: An In Vitro Mechanobiology Study

Mesenchymal stem/stromal cell-derived extracellular vesicles (MSC-EVs) are emerging as cell-free therapeutic candidates for osteoarthritis, but most approaches treat the secretome as a passively collected product rather than a tunable biologic. Because joint loading regulates car...

Sex-specific patterns of symptom burden, psychological distress, and work productivity impairment in post-acute sequelae of COVID-19: a 10-month dynamic cohort study

Abstract Background A considerable proportion of patients experience post-acute sequelae of COVID-19 (PASC). Increasing evidence suggests sex-related differences, yet systematic longitudinal analyses remain limited. This study aimed to examine sex-specific differences in symptoms...

FOXC1 and its lncRNA FOXCUT link DNA methylation to a chondrocyte phenotype dysfunction

Abstract Objective With current osteoarthritis (OA) therapies limited to symptom management, understanding molecular drivers of disease progression is critical. As epigenetic mechanisms increasingly appear central to OA pathogenesis, this study aimed to identify epigenetically dy...

Utilization of Carbon Fiber Spinal Instrumentation in Primary Spinal Tumors: Outcome Analysis from the AO Spine Primary Tumor Research and Outcomes Network

Background The use of carbon fiber-reinforced polyetheretherketone (CFR-PEEK) instrumentation in spinal surgery has emerged as an alternative to traditional titanium-based implants in recent years. This study aims to evaluate the use and performance of carbon fiber instrumentatio...

Position-Dependent Stability of an Unconstrained Total Talar Replacement and Its Suture Reinforcement: A Human Cadaveric Weight-Bearing Computed Tomography Study

Total talar replacement (TTR) is a joint-preserving alternative to arthrodesis in end-stage talar collapse. However, excising the talus detaches its anchoring ligaments and capsule, and unconstrained prosthesis constructs are prone to malalignment and dislocation. Moreover, it re...

Establishment of a human osteocyte model to reveal mechanisms of chronic Staphylococcus epidermidis bone and joint infections

Aims Chronic bone and joint infections caused by Staphylococcus epidermidis can be difficult to treat and are prone to recurrence. In this study, established human osteoblast- and osteocyte-like cell line models were used in vitro to investigate the intracellular persistence of S...

Effect of distal screw number on axial deformation and fragment-specific stability in AO/OTA 2R3 C2.1 distal radius fractures

PURPOSE: To investigate the biomechanical influence of distal screw number in palmar plate fixation of unstable intra-articular distal radius fractures with radiodorsal metaphyseal comminution. METHODS: Nine matched pairs of cryopreserved human radii were prepared using a standar...