Anyang Hospital of Traditional Chinese Medicine

Molecular Insights into the Bacterial Membrane Interactions of Proline-Stabilized Graphene: Effects of Proline Oligomerization

Abstract Multidrug-resistant bacterial infections pose a major global health challenge. Graphene nanosheets exhibit promising antibacterial activity through membrane disruption, but their practical application is limited by poor aqueous stability and biocompatibility. A recent st...

Screening and ARTP mutagenesis-based breeding of high-cellulase-producing strains

Abstract While lignocellulose is an abundant renewable resource, the discovery of microorganisms capable of degrading lignocellulose is important for its full utilization. In this study, 26 soil samples were collected from Jigongshan National Nature Reserve, Xinyang, China. The C...

Topologically distinct intratumoral heterogeneity scores for predicting high-risk pathological grades in invasive lung adenocarcinoma: A multicenter study across four institutions

High-risk subtypes of invasive lung adenocarcinoma (IAC), particularly micropapillary- or solid-predominant patterns, are closely associated with poor prognosis. This multicenter retrospective study developed and validated a predictive model for the preoperative identification of...

Clinical practice guidelines for nephrotic syndrome: systematic assessment of their quality and the concordance between certainty of evidence levels and strength of recommendations

Clinical practice guidelines (CPGs) aim to provide appropriate clinical practice recommendations based on available evidence while acknowledging existing gaps and uncertainties. However, the quality of CPGs for nephrotic syndrome (NS) remains unknown, and the distribution of evid...

SHP2 accelerated acute liver injury via modulating TGFβ1/EZH2/BRD4 signaling induced proliferation and fibrosis of HSC

To explore the specific molecular mechanisms by which SHP2 promotes liver injury. Single-cell transcriptomics and bioinformatics analyses were employed for predictive screening. C57BL/6J mice were assigned to normal, model, and model+PHPS1 groups. Liver injury and fibrosis were e...

SEMS bridge to elective laparoscopic surgery versus emergency surgery for obstructive colorectal cancer: a propensity score-matched retrospective cohort study

BACKGROUND: This study compared perioperative recovery and clinical outcomes of patients with obstructive colorectal cancer (OCRC) undergoing self-expandable metallic stent (SEMS) placement followed by elective laparoscopic resection versus emergency surgery. METHODS: Between Jan...

Surgical approaches for screw fixation of calcaneal fractures: a systematic review

To systematically review and summarize the evidence related to different screw configurations in the internal fixation treatment of calcaneal fractures. This systematic review (PROSPERO registration CRD420261389986) employed a comprehensive literature search of PubMed/MEDLINE, Em...