Institution
Anhui Provincial Hospital
Recent research
- Health & MedicineOpen access
Diagnostic value of plasma TFF3‐centered combined biomarker panel in early gastrointestinal cancer
ABSTRACT Gastrointestinal (GI) tumors represent a significant global health burden, necessitating robust strategies for early detection. However, the clinical utility of conventional protein biomarkers such as carcinoembryonic antigen (CEA), carbohydrate antigen 19‐9 (CA19‐9) in...
- Health & Medicine
BACKGROUND: Haemophilic arthropathy (HA) is a chronic joint disease in haemophiliac patients, driven by recurrent bleeding and distinct from osteoarthritis (OA) and rheumatoid arthritis (RA) in its pathogenesis, including metal ion accumulation and inflammatory responses. AIM: To...
- Health & MedicineOpen access
Enteric protozoan infections-cryptosporidiosis, giardiasis, microsporidiosis, and coccidiosis-constitute a significant global burden on human and animal health. Yet comprehensive parasitological surveys of wildlife in the eastern Tibetan Plateau, where anthropogenic, livestock, a...
- BiologyOpen access
Colorectal cancer (CRC) is a highly heterogeneous malignancy with a poor prognosis. Although previous studies have suggested that circular RNA hsa_circ_0001944 is involved in CRC progression, its precise biological role remains unclear. This study aimed to investigate the functio...
- Health & MedicineOpen access
Patients with esophageal squamous cell carcinoma (ESCC) have an unmet need for new therapies that improve survival. In this phase II trial, patients received ociperlimab and tislelizumab (A) or placebo and tislelizumab (B) (NCT04732494). The primary endpoint was objective respons...
- Materials & Energy
Abstract The rational design of highly stable and selective molybdenum-based catalysts for propane dehydrogenation (PDH) remains a major challenge, due to severe intraparticle mass transfer limitations and rapid deactivation driven by active site volatilization and coking. Here,...
- Health & MedicineOpen access
Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer
IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...
- Health & MedicineOpen access
To explore the anatomy and design of a lumbogluteal fasciocutaneous flap with a pedicle based on the fourth lumbar artery perforator and neurotrophic vascular network. Based on the anatomic findings of the lumbogluteal region in 15 human cadavers, a special lumbogluteal fasciocut...
- BiologyOpen access
Innovative treatment strategies for impacted maxillary central incisor and case comparisons
Background: The present article compares innovative treatment strategies for impacted maxillary central incisors, emphasizing the critical importance of prioritizing root development over rapid crown alignment. Methods: Two case reports using distinct clinical approaches are pres...
- Health & MedicineOpen access
Intermittent fasting promotes plaque regression and activates the BMAL1–MERTK efferocytosis axis
Abstract Background Atherosclerotic cardiovascular disease can progress despite intensive lipid lowering, highlighting the need to identify local mechanisms that remodel established plaques. Intermittent fasting may engage metabolic, circadian, and immune pathways relevant to thi...
- Engineering & TechnologyOpen access
Abstract Osseointegration between titanium implants and surrounding bone is essential for the long-term success of implant surgery. However, mechanical injury during implantation can induce local oxidative stress, which compromises peri-implant osteogenesis. In this study, we dev...
- Health & MedicineOpen access
Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...
- Health & MedicineOpen access
The progression of cardiovascular disease shows significant sexual dimorphism: although females generally develop the disease later in life, they exhibit a higher age-related incidence than males. While current studies have separately reported sex differences in atherosclerotic d...