Andreas Sygros Hospital

Upcoming novel treatments for hidradenitis suppurativa: An overview of the pipeline

Abstract Recent developments in hidradenitis suppurativa (HS) have focused on targeting key inflammatory pathways implicated in the pathogenesis of the disease, including interleukin (IL)‐17, IL‐1, tumour necrosis factor (TNF), Janus kinase (JAK) and tyrosine kinase 2 (TYK2) sign...

Diagnostic Performance of the Lymphocyte Transformation Test and Patch Testing in Delayed Hypersensitivity Drug Reactions

Background: Cutaneous adverse drug reactions (CADRs) occur in 2–5% of inpatients, primarily due to delayed (T-cell-mediated) reactions, such as maculopapular exanthemas (MPEs). The lymphocyte transformation test (LTT) detects drug-specific T-cell responses with varied sensitivity...

Dermatologic Toxicities Associated with Tebentafusp for Uveal Melanoma: A Review of Clinical Trials and Real-World Evidence

Tebentafusp is a first-in-class bispecific fusion protein that redirects T cells toward gp100-expressing cells and represents the first systemic treatment shown to improve overall survival in patients with HLA-A*02:01-positive metastatic uveal melanoma. As gp100 is also expressed...

Glucocorticoids: an enemy or a friend for the dermatologist? recommendations for proper use and safe discontinuation

Abstract Purpose Glucocorticoids (GCs) are steroid hormones produced by the adrenal cortex with anti-inflammatory and immunoregulating effects, thus essential for the management of numerous inflammatory and autoimmune disorders, including a wide range of dermatological conditions...

Cytotoxic Effects of Carboxyl-Modified Polystyrene Microplastics: Differential Effects on Hepatoma Cells and Immortalized Hepatocytes

Carboxyl-modified polystyrene microplastics (cPS-MPs) may accumulate in the liver and interfere with cellular metabolism; however, their effects may differ substantially between cancerous and non-cancerous hepatocytes. In this study, we compared the responses of HUH-7 hepatocellu...

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...