Analysis Group (United States)

Sex and racial disparities in clinical outcomes and health resource use among patients with primary biliary cholangitis in the United States.

BACKGROUND: Racial and sex disparities have been described in liver conditions, including primary biliary cholangitis (PBC). This study sought to understand how race/ethnicity and sex-based differences impact access to diagnosis, clinical outcomes, health resource use (HRU), and...

Real-World Treatment Patterns in Patients with Spinal Muscular Atrophy Receiving Multiple Disease-Modifying Therapies

Nusinersen (approved in 2016), onasemnogene abeparvovec (intravenous infusion [OAV], 2019; intrathecal injection, 2025), and risdiplam (2020) are disease-modifying therapies (DMTs) available in the US for spinal muscular atrophy (SMA). Real-world evidence on treatment patterns am...

High pre-frailty burden among people living with HIV in Botswana

Frailty is increasingly recognized as a significant aging-related condition in people living with HIV (PLWH), but data from sub-Saharan Africa (SSA) - where the majority of PLWH reside - remain limited. Using standardized Fried frailty criteria, we assessed the prevalence and fac...

Adverse events, quality of life, and work impairment in patients with chronic myeloid leukemia (CML)—a survey of first- and second-line tyrosine kinase inhibitor (TKI) intolerance in the US

Tyrosine kinase inhibitors (TKIs) improve survival for people with chronic myeloid leukemia (CML) but may cause adverse events (AEs) that impair quality of life (QoL). Adults with CML receiving first- or second-line TKI therapy in the United States (US) completed validated questi...

The Superhumans: Artificial Cognitive Amplification, Concentration of Agency, and Systemic Risk in the Era of Autonomous Agents

The dominant debate on the risks of artificial intelligence (AI) frequently centers on the possibility that highly capable, autonomous systems come to act in ways incompatible with human interests. This paper examines an earlier and potentially complementary transition: the ampli...

When Empiric Therapy Fails: Clinical and Economic Consequences in uUTIs Among US Women

Uncomplicated urinary tract infection (uUTI) management is increasingly challenging due to antibiotic treatment failure (TF). This retrospective, observational cohort study used Optum’s de-identified Electronic Health Record dataset (January 2017–September 2022) to investigate th...

Incidence of Invasive Pneumococcal Disease in US Children by Risk Group, 1998-2023

Abstract Background Children with risk conditions are vulnerable to invasive pneumococcal disease (IPD) and are targeted for routine and supplemental pneumococcal vaccination. This study aimed to quantify the incidence of IPD in US children by risk group since PCV introduction. M...

Clinical Remission is Achievable for Adult Patients with Severe Asthma Receiving Mepolizumab: A European Retrospective Chart Review

The introduction of precision therapy in severe asthma is shifting treatment goals from asthma control towards the more ambitious target of clinical remission. This study evaluated clinical remission in patients with severe asthma receiving mepolizumab in Europe. A retrospective,...

How low do you need to go? Association between various prostate‐specific antigen response measures and clinical outcomes in metastatic castration‐sensitive prostate cancer in the Veterans Health Administration data

BACKGROUND: Multiple phase 3 metastatic castration-sensitive prostate cancer (mCSPC) studies consistently show a prostate-specific antigen (PSA) nadir of <0.2 ng/mL to be the preferred threshold for PSA response. However, in real-world practice, physicians often use other metrics...