Amsterdam University of Applied Sciences

Home-based geriatric rehabilitation after shortened inpatient rehabilitation: cost-effectiveness analysis of the “Better@Home” multicentre prospective cohort study with a matched historical control group

PURPOSE: Geriatric rehabilitation (GR) is facing increased demand due to population ageing. Home-based GR could reduce reliance on resource-intensive inpatient care. However, evidence is limited regarding the cost-effectiveness of home-based GR. The aim of this study is to assess...

Innovation adoption across regions: psychological openness and the early diffusion of digital platforms

Early regional adoption is crucial for platform-enabled innovations because their viability depends on enough people within a region adopting them to generate network effects. Existing research on regional innovation diffusion explains early adoption largely through demographic,...

Perceptions of a New Boundary-Crossing Professional in Early Childhood Education and Care

There is a growing trend in which new professional roles complement traditional ones to bridge education, childcare, and social care. In the Netherlands, this is reflected in the introduction of the Pedagogical Educational Professional (PEP) as a boundary-crossing professional in...

Generation and Functional Characterization of Cadaver-Derived iPSC-Cardiomyocytes: A Feasibility Study Toward Functional Molecular Autopsy in Sudden Cardiac Death

Sudden cardiac death (SCD) accounts for a substantial share of deaths in young individuals. Despite postmortem pathological, toxicological, and forensic examination and molecular autopsy, many cases remain unexplained, highlighting the need for complementary approaches to investi...

“Now You Know, Don't Be Indifferent”: The Emotional Correlates of Learning About Historical Violence and Their Relationship With Current Prosocial Motivation

ABSTRACT How does learning about historical violence inspire prosocial action today? Prior work has focused on whether such experiences are (emotionally) impactful but seldom tested the mechanisms of impact. We propose a framework of actor‐specific emotional pathways connecting k...

Implementing environmentally sustainable behavior in healthcare: an illustration of why behavioral definitions matter

Abstract Background Implementing more sustainable practices is crucial for reducing the environmental footprint of the healthcare sector. While organizational factors such as availability of sustainable materials are important, healthcare professionals’ adoption of sustainable be...

Machine Learning-Guided Discovery of Robust Conditions for Photochemical Nickel-Catalyzed Cysteine Arylation

Abstract Late-stage functionalization (LSF) of peptides offers direct access to structurally diverse analogues, but developing general, chemoselective protocols remains challenging due to the complexity of peptide substrates and the vast number of reaction variables. Traditional...

More than just smiling: how positive emotions are expressed on the face

To advance the science of positive emotional expressions, we test how 22 positive emotions are spontaneously displayed on the face, using the participant-negotiated episodic recall method. Respondents (n = 163) narrated emotional events from their lives, and we extracted facial b...

Discussing menopausal symptoms at work and associations with taboo, symptom severity, and need for recovery after work

Objective: Although the impact of menopausal symptoms at work is increasingly recognized, it remains unclear to what extent and with whom menopausal symptoms that limit work functioning are discussed. We examined this and explored associations with taboo, symptom severity, and ne...

Heart failure with a preserved ejection fraction: synergy between cardiac and extracardiac mechanisms and effects of novel therapies

Heart failure with preserved ejection fraction (HFpEF) is a systemic disease in which metabolic comorbidities obesity, type 2 diabetes (T2D), and chronic kidney disease (CKD) converge to drive systemic inflammation, endothelial dysfunction, and myocardial fibrosis. Microvascular...

Minimally invasive needle arthroscopy versus conventional arthroscopy for treatment of bacterial knee arthritis: protocol of a pragmatic, multicenter, randomized, controlled, non-inferiority trial (MINA-TRIAL)

Abstract Background Recent innovation offers the possibility for joint drainage under local anaesthesia for the treatment of bacterial arthritis of the native knee, using minimally invasive needle arthroscopy (MINA). Compared with conventional arthroscopy, MINA enables immediate...

Case-based pharmacotherapeutic learning structured around the prescribing optimization method and the WHO 6-step model: Medical students’ views from an exploratory questionnaire study

Abstract Purpose Pharmacotherapy is a core competence for physicians and case-based learning is a valuable teaching method for developing this competence. This study explored medical students’ views on structuring pharmacotherapeutic education around either the Prescribing Optimi...

From epidemiology to phenotyping: Characterizing neurologic dysfunction in Sub-Saharan Africans with HIV

Background Neurological complications remain an important manifestation of HIV infection, particularly as advances in diagnosis and antiretroviral therapy have increased survival. Despite this, neurological research in sub-Saharan Africa has remained largely focused on describing...

A novel framework to modelling regulation of prey populations by a generalist predator

Abstract Background In ecological communities, a predator often feeds on several food sources. Such a predator is known as a generalist, and its feeding is traditionally modelled by a functional response. However, the conventional concept of the functional response is not applica...

The Role and Assessment of Lipid Profile in Patients With a Chronic Total Coronary Occlusion

ABSTRACT Adequate lipid management is a crucial component in the treatment of chronic coronary syndromes, a group of conditions that also encompasses patients with chronic total coronary occlusions (CTOs). Importantly, atherosclerotic progression may be especially rapid in patien...

Seeding Norms by Making the Invisible Visible in a Field Study on Pro-Environmental Change

Most people are concerned about environmental issues, but underestimate others’ concern due to a lack of visible pro-environmental behaviour. This misperception creates a cycle of inaction, as people are less likely to act sustainably when they assume others do not share their pr...

Early‐stage myocardial changes are not aggravated by Western diet or ageing in Mybpc3 c.2373insG heterozygous mice

Abstract Hypertrophic cardiomyopathy (HCM) caused by heterozygous pathogenic gene variants is characterized by highly variable disease phenotypes. Ageing and systemic metabolic disruption are thought to act as additional ‘second hits’ that modulate this genotype–phenotype relatio...

Effects of exercise on muscle strength and characteristics in rheumatic diseases and sarcopenia: Protocol for the Care for Muscle (C4M) Study

Objective Muscle weakness is prevalent in rheumatoid arthritis (RA), osteoarthritis (OA) and sarcopenia (SARC). Endurance exercises may improve mitochondrial function and oxidative capacity, while strength exercises are thought to stimulate myofibrillar protein synthesis. This st...

The Unequal Selves Model: How Children Develop Self-Views in an Age of Economic Inequality

Economic inequality is on the rise globally. How do children form self-views in an age of economic inequality? I offer a developmental model—the Unequal Selves Model—addressing this question by bridging insights from the psychological, educational, and sociological literatures. T...

An Open Database of Lunar Regolith and Simulants Properties

ABSTRACT Lunar regolith, the layer of unconsolidated material covering the Moon's surface, is central to the science and technology developed for the Moon, notably related to in‐situ science investigations, resource utilization, surface infrastructure, and mobility systems. Howev...