Amgen (United States)

Electrochemical Platform for Automated Design-of-Experiment Optimization of Ni-Catalyzed Cross-Electrophile Coupling Reactions

Abstract Electrosynthetic organic reactions have advanced significantly in recent years, but their adoption for large-scale applications remains limited. Here, we report an automated experimental platform designed to facilitate translation of small-scale chemical and electrochemi...

Tarlatamab in small cell lung cancer following platinum-based chemotherapy: subgroup analysis of Japanese patients from the DeLLphi-304 study

Abstract Background In the Phase 3 DeLLphi-304 trial, tarlatamab significantly improved overall survival (OS) over chemotherapy for small-cell lung cancer (SCLC) progressed after platinum-based chemotherapy. We report efficacy and safety in the Japanese subpopulation. Methods Pat...

A phase 4, open-label efficacy and safety study of methotrexate and monthly pegloticase co-administration in patients with uncontrolled gout

Abstract Background Pegloticase is an infused pegylated uricase enzyme indicated for the treatment of uncontrolled gout in adults who did not respond to or cannot tolerate oral urate-lowering therapies; pegloticase is administered as 8-mg infusions every 2 weeks (Q2W). However, f...

Setting a Fill Weight Target and Control Limits for Drug Product Presentations

For a given drug product presentation, the design of the fill weight strategy is a critical element to ensure that patients receive the correct dose. The fill weight strategy is comprised of fill weight target selection and the action limits around the target. Health regulatory a...

Machine learning–driven spleen imaging and genomics uncover a splenic connection to coronary artery disease

Despite advances in managing traditional risk factors, coronary artery disease (CAD) remains the leading cause of mortality. Circulating hematopoietic cells influence risk for CAD separately from traditional risk factors, but the role of a key regulating organ, the spleen, is unk...

Effects of Evolocumab on Mortality Outcomes in Patients Without Previous Myocardial Infarction or Stroke: A Prespecified Analysis of the VESALIUS-CV Randomized Clinical Trial

BACKGROUND: Evolocumab, a PCSK9 (proprotein convertase subtilisin–kexin type 9) inhibitor, significantly reduced the risk of cardiovascular events in patients without previous myocardial infarction or stroke in the VESALIUS-CV trial (Effect of Evolocumab in Patients at High Cardi...

Modernizing the Institutional Review Board Process for Implementation Science – A Narrative Review of Barriers and Ethical Considerations

Abstract Purpose of Review This review highlights the barriers and facilitators that implementation science studies face in the institutional review board (IRB) approval pathway and provides recommendations on how to potentially streamline this process. Recent findings Significan...

Osteoporotic fracture, diagnostic activity, and treatment in patients with gout

BACKGROUND: Patients with gout may be at high risk for developing osteoporosis and osteoporotic fractures, but osteoporosis may be under-recognized and inadequately managed for patients with gout. We aimed to describe osteoporotic fractures and diagnosis, DXA utilization, and bon...

FullMS2Former:A Transformer Model for Near-CompletePrediction of Peptide Tandem Mass Spectra

Abstract Accurate prediction of peptide tandem mass spectra is essential for confident peptide identification. Existing deep learning models achieve high similarity to experimental spectra but remain constrained by fixed fragment dictionaries of common fragment ions, limiting the...