American University of the Caribbean School of Medicine

Treat (the whole of) me: a systematic review and qualitative meta-ethnographic synthesis of the experiences of women with POP, SUI or mesh complications in the context of surgical treatment

Abstract Background Stress Urinary Incontinence (SUI) and Pelvic Organ Prolapse (POP) are common pelvic floor disorders that may significantly impact women’s quality of life. Surgical interventions are available to treat these conditions, some using synthetic mesh. Whilst most wo...

Selective Neuronal Vulnerability to Alpha-Synuclein Pathology in Parkinson’s Disease: A Critical Review of Mechanistic Rationale and Biomarker Stratification

Background: Parkinson’s disease (PD) exhibits remarkable clinical heterogeneity, with substantial variability in motor progression, cognitive decline, and the development of non-motor manifestations. Although the propagation of pathological alpha-synuclein is considered a central...