American Pharmacists Association Foundation

Camptodactyly-arthropathy-coxa vara-pericarditis syndrome masquerading as juvenile idiopathic arthritis: Clinical, familial, and genetic spectrum of a Libyan case series

Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome is a rare autosomal recessive disorder associated with biallelic pathogenic variants in PRG4, encoding proteoglycan 4 (lubricin). Progressive joint enlargement, restricted mobility, and synovial involvement may clos...

Camptodactyly-arthropathy-coxa vara-pericarditis syndrome masquerading as juvenile idiopathic arthritis: Clinical, familial, and genetic spectrum of a Libyan case series

Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome is a rare autosomal recessive disorder associated with biallelic pathogenic variants in PRG4, encoding proteoglycan 4 (lubricin). Progressive joint enlargement, restricted mobility, and synovial involvement may clos...

Imbalance of oxidative stress and its role in Parkinson's disease

Parkinson's disease (PD) is the greatest shared neurodegenerative disease affecting millions of individuals in the world, and it is linked to the continual deterioration of dopaminergic neurons in the Substantia nigra (SN) pars compacta. Despite years of intensive study, the deta...

Imbalance of oxidative stress and its role in Parkinson's disease

Parkinson's disease (PD) is the greatest shared neurodegenerative disease affecting millions of individuals in the world, and it is linked to the continual deterioration of dopaminergic neurons in the Substantia nigra (SN) pars compacta. Despite years of intensive study, the deta...

Kisspeptin signalling in male reproduction: Molecular mechanisms, biomarker potential, and therapeutic opportunities

Abstract: Kisspeptin, a peptide encoded by the KISS1 gene, has emerged as a principal regulator of the hypothalamic-pituitary-gonadal axis and plays a fundamental role in male reproductive physiology. Beyond its established function in stimulating gonadotropin-releasing hormone s...

Kisspeptin signalling in male reproduction: Molecular mechanisms, biomarker potential, and therapeutic opportunities

Abstract: Kisspeptin, a peptide encoded by the KISS1 gene, has emerged as a principal regulator of the hypothalamic-pituitary-gonadal axis and plays a fundamental role in male reproductive physiology. Beyond its established function in stimulating gonadotropin-releasing hormone s...

In vitro evaluation of the inhibitory effect of phenolic acids on protein glycation: A potential strategy for reducing diabetic complications

Advanced glycation end-products are harmful compounds formed through non-enzymatic reactions between sugars and proteins. Their accumulation, particularly under hyperglycemic conditions, contributes significantly to oxidative stress and chronic complications in diabetes mellitus....

In vitro evaluation of the inhibitory effect of phenolic acids on protein glycation: A potential strategy for reducing diabetic complications

Advanced glycation end-products are harmful compounds formed through non-enzymatic reactions between sugars and proteins. Their accumulation, particularly under hyperglycemic conditions, contributes significantly to oxidative stress and chronic complications in diabetes mellitus....

Overweight and obesity prevalence in North Africa: A systematic review and meta-analysis

North Africa is experiencing an accelerating obesity epidemic driven by nutrition transition, urbanization, and changing lifestyle patterns. Overweight and obesity are now leading risk factors for NCDs across all five target nations. No contemporary PRISMA-compliant systematic re...

Revolutionizing pharmaceutical innovation through artificial intelligence: Transforming drug discovery and development

Artificial intelligence (AI) has become an effective tool that leverages personal information to deliver faster solutions to complex problems. A revolutionary approach to drug discovery, formulation, and dosage form testing is presented by promising advances in machine learning a...

Revolutionizing pharmaceutical innovation through artificial intelligence: Transforming drug discovery and development

Artificial intelligence (AI) has become an effective tool that leverages personal information to deliver faster solutions to complex problems. A revolutionary approach to drug discovery, formulation, and dosage form testing is presented by promising advances in machine learning a...

Chemical composition and amino acid analysis of the seeds of the milk thistle plant (Silybum marianum Gaertn L.) widespread in Tulkarem, Palestine

In this study, the milk thistle (Silybum marianum Gaertn L.), widespread in Palestine, was selected to study the basic qualitative chemical composition of aqueous, ethanol, chloroform, and hexane extracts from its seeds, and to identify the active compounds present. The results o...

The burden of dyslipidaemia in an urban Libyan population: Epidemiological assessment and a review of modern therapy

Dyslipidemia is a major modifiable risk factor for cardiovascular disease, yet data from Libyan populations remain limited. This study aims to investigate the prevalence, patterns, and demographic determinants of dyslipidemia among residents of Zawia City, Libya, and to provide a...

Willingness and barriers to COVID-19 vaccination among Libyan adults: A cross-sectional survey

The success of COVID-19 vaccination programs depends on public acceptance, yet evidence from southern Libya remains limited. This study aimed to examine public perceptions, attitudes, and willingness toward COVID-19 vaccination among adults in urban and rural areas of southern Li...

Knowledge, attitude, and practice on the use of contact lenses among youths in Ughelli North Local Government Area, Delta State, Nigeria

This study investigated the knowledge, attitude, and perception of contact lens use among youths in Ughelli North LGA, Delta State, Nigeria. A cross-sectional survey involving 386 respondents aged 15-30 years was conducted using a structured questionnaire. Data were analyzed usin...