American College of Healthcare Executives

The Clearance Hypothesis: Impaired Systemic Clearance as a Driver of Chronic Disease

The Clearance Hypothesis proposes that impaired clearance capacity — not merely genetic predisposition or isolated organ dysfunction — is a primary driver of chronic disease progression. This document presents a comprehensive master synthesis mapping eight core clearance systems...

The Clearance Hypothesis: Impaired Systemic Clearance as a Driver of Chronic Disease

The Clearance Hypothesis proposes that impaired clearance capacity — not merely genetic predisposition or isolated organ dysfunction — is a primary driver of chronic disease progression. This document presents a comprehensive master synthesis mapping eight core clearance systems...