American Association of Colleges of Pharmacy

Evaluation of Antiviral Drugs’ Central Nervous System Distribution Using In Vitro Blood–Brain and Blood-CSF Barrier Models: The Impact of Serum Protein Concentration

The blood–brain barrier (BBB) and blood–cerebrospinal fluid barrier (BCSFB) are dynamic neurovascular interfaces that maintain central nervous system (CNS) homeostasis by tightly regulating paracellular and transcellular molecular transport. Intercellular communication between ad...

Psychosocial interventions for antiretroviral therapy adherence in people living with HIV in West Africa: a scoping review and bibliometric analysis

Human immunodeficiency virus (HIV) compromises the immune system and remains a major cause of morbidity and mortality. While antiretroviral therapy (ART) is accessible to many individuals, inadequate adherence continues to compromise viral suppression, especially in resource-limi...

Beta-Lactam Dose Optimization Using Therapeutic Drug Monitoring in Pediatric Patients

OBJECTIVE: Beta-lactam therapeutic drug monitoring (BL-TDM) is underused in pediatric patients where drug exposure is highly variable. This study evaluated the pharmacokinetic/pharmacodynamic (PK/PD) target attainment of BLs in pediatrics. PATIENTS AND METHODS: A retrospective ob...

A designer pore-blocking peptide reveals an electrostatic complementation mechanism for the inhibition-resistant Kv1.5 channel

Most voltage-gated potassium (Kv) channels are inhibited by peptide neurotoxins that occlude the pore with a positively-charged lysine. Kv1.5 repels these toxins electrostatically via four arginines (R487), one on each pore-forming subunit. Here, we describe chimera toxin (CmTx),...

Knowledge, attitude, and practice of antifungal resistance and stewardship among pharmacy students in Zambia: a cross-sectional study to inform antifungal stewardship programs

Background Antifungal resistance (AFR) is a growing global health threat, particularly in low- and middle-income countries such as Zambia, where antifungals are often accessed without prescription. Antifungal stewardship (AFS) programs aim to optimise antifungal use, yet limited...

Tramadol Co‐Administration with Oxycodone or Hydrocodone Increases Opioid Burden without Improving Postoperative Pain Control

Tramadol is frequently co-prescribed with oxycodone or hydrocodone after surgery under the assumption that its dual mechanism of action provides an opioid-sparing benefit. However, evidence supporting this practice is limited and inconsistent. We conducted a secondary analysis of...

LPR-1-Mediated targeted intranasal delivery of lentinan-loaded polymeric nanocarriers for GBM therapy via modulation of apoptotic signalling

Aim To develop and evaluate a lactoferrin (Lf)-functionalized polyethylene glycol (PEG)-grafted chitosan (CS) nanocarriers (NCs) for low-density lipoprotein receptor-related protein-1 (LRP1)-mediated intranasal delivery of lentinan (LNT) to enhance brain targeting and anti-gliobl...