Alzheimer’s Disease Neuroimaging Initiative

The MoCA Memory Index Score (MIS) as an indicator of episodic memory impairment and its implications for cognitive screening in a mixed clinical sample

OBJECTIVE: The Montreal Cognitive Assessment (MoCA) Memory Index Score (MIS) has shown promise as a brief indicator of episodic memory decline, but its correspondence with standardized neuropsychological memory measures in diagnostically heterogeneous clinical populations remains...

International variation in neuropsychological test use practices: Implications for test adaptation and fair assessment

Neuropsychological test selection varies substantially across countries and languages, yet which instruments clinicians use internationally remains poorly documented. Using a survey of International Neuropsychological Society members (INSConnect, 2023), we examined instrument end...

Artificial Intelligence–Based Detection of ARIA on MRI During Alzheimer Disease Therapy: Expert Opinion on Responsible Clinical Integration

Amyloid-targeted monoclonal antibody therapies have introduced a new era in the treatment of early Alzheimer disease. However, their use has increased the importance of detecting and monitoring amyloid-related imaging abnormalities (ARIA) on MRI, as such findings may influence tr...

One-week changes on the Independent Living Scales in older adults: Proof of concept for quantifying subtle functional decline

Objective: Identifying subtle change in daily functioning is important for diagnosing late life cognitive disorders. This proof-of-concept study sought to develop standardized regression-based (SRB) equations for the Independent Living Scales (ILS) and examine their application i...

From feasibility to neuroanatomic validity of remote cognitive smartphone assessments in early Alzheimer’s disease

ABSTRACT Digital health technologies (DHT) offer a promising solution to the timely identification of early Alzheimer’s disease (eAD) to enable early treatment. This study evaluated the feasibility, acceptability, adherence, reliability, and preliminary clinical and content valid...

Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations

Accumulation of abnormal tau protein into neurofibrillary tangles (NFTs) is a pathologic hallmark of Alzheimer disease (AD). Accurate detection of NFTs in tissue samples can reveal relationships with clinical, demographic, and genetic features through deep phenotyping. However, e...

Evidence-based interventions for vocational recovery in first-episode psychosis: A meta-analysis of employment and education rates

Background: Young people with first-episode psychosis experience high rates of disruption in work and education and consistently describe vocational participation as a core priority of recovery. This meta-analysis aimed to evaluate the effectiveness of evidence-based intervention...