Altrincham Hospital

Resolving Hidden Stoichiometriesin Bacterial ProteasomeActivator (Bpa)-Substrate Complexes by Cryo-EM and Charge DetectionMass Spectrometry

Abstract Bacterial proteasome activator (Bpa) is a regulatory particle within the Mycobacterium tuberculosis (Mtb) proteasome system that facilitates ATP-independent substrate engagement and delivery to the 20S core particle (CP) for degradation. The best characterized Bpa substr...