Allegheny General Hospital

Why 30 mg Twice Daily Fails: Anti-Factor Xa Monitoring and the Persistent Dosing Gap in High-Risk Trauma Patients

Introduction Contemporary trauma guidelines support higher initial enoxaparin dosing for adult trauma patients, as standard dosing (30 mg twice daily [BID]) frequently fails to achieve target anticoagulant activity. While anti-factor Xa (anti-Xa) monitoring guides dose adjustment...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...