Allama Iqbal Medical College

Bibliometric mapping of the 100 most-cited publications on optic nerve and optic pathway glioma

Background: Optic pathway gliomas (OPGs), including optic nerve gliomas, are uncommon tumors of the anterior visual pathway that arise mainly in young children, often with neurofibromatosis type 1 (NF1). The literature is now substantial, but its structure is undescribed. We mapp...

Anesthetic Approaches for Left Atrial Appendage Occlusion: Comparing Conscious Sedation and General Anesthesia: A Meta Analysis

Background Left atrial appendage occlusion (LAAO) offers a mechanical alternative to anticoagulation for stroke prevention in nonvalvular atrial fibrillation patients. However, the optimal anesthetic strategy—general anesthesia (GA) versus conscious sedation (CS)—during LAAO rema...

Efficacy of rituximab plus lenalidomide regimens in follicular lymphoma: a meta-analysis of randomized controlled trials

Follicular lymphoma (FL) is an incurable, indolent non-Hodgkin lymphoma with a high relapse rate despite effective chemoimmunotherapy. Lenalidomide, an immunomodulatory agent, in combination with rituximab (R²), has been evaluated as an alternative to chemoimmunotherapy and to ot...

Effect of renal denervation in chronic kidney disease: a systematic review, time-stratified meta-analysis and meta-regression of blood pressure and renal outcomes

Hypertension in chronic kidney disease (CKD) is frequently resistant to pharmacologic therapy, with sympathetic overactivity contributing to both elevated blood pressure (BP) and renal disease progression. Renal denervation (RDN) targets renal sympathetic nerves and may provide d...

Active gut microbiota resistome identified by metatranscriptomics and its contribution to antimicrobial resistance

Abstract The global health crisis of antimicrobial resistance (AMR) is compounded by gut microbiota, which acts as a reservoir for antibiotic-resistant genes (ARGs). While DNA-based metagenomics can identify the potential for resistance, the resistome, it cannot determine the ARG...

Left Atrial Myopathy as a Phenotypic Axis in HFpEF: Implications for Pulmonary Hypertension, Exercise Intolerance, and Targeted Therapy

Heart failure with preserved ejection fraction (HFpEF) is a highly heterogeneous syndrome characterized by impaired ventricular relaxation, systemic inflammation, and multisystem cardiovascular dysfunction. Despite growing recognition of HFpEF as a major global health burden, eff...

Renal outcomes of SGLT2 inhibitors in ADPKD: a narrative review from mechanistic rationale to clinical trials

Abstract Inhibitors of the sodium-glucose cotransporter-2 (SGLT2i) were initially created for managing diabetes mellitus but have suggested significant renoprotective advantages regardless of blood glucose levels. SGLT2-inhibitors have thus emerged as a crucial component in the t...