Allama Iqbal Medical College

Active gut microbiota resistome identified by metatranscriptomics and its contribution to antimicrobial resistance

Abstract The global health crisis of antimicrobial resistance (AMR) is compounded by gut microbiota, which acts as a reservoir for antibiotic-resistant genes (ARGs). While DNA-based metagenomics can identify the potential for resistance, the resistome, it cannot determine the ARG...

Left Atrial Myopathy as a Phenotypic Axis in HFpEF: Implications for Pulmonary Hypertension, Exercise Intolerance, and Targeted Therapy

Heart failure with preserved ejection fraction (HFpEF) is a highly heterogeneous syndrome characterized by impaired ventricular relaxation, systemic inflammation, and multisystem cardiovascular dysfunction. Despite growing recognition of HFpEF as a major global health burden, eff...

Renal outcomes of SGLT2 inhibitors in ADPKD: a narrative review from mechanistic rationale to clinical trials

Abstract Inhibitors of the sodium-glucose cotransporter-2 (SGLT2i) were initially created for managing diabetes mellitus but have suggested significant renoprotective advantages regardless of blood glucose levels. SGLT2-inhibitors have thus emerged as a crucial component in the t...