All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Asymmetric Metal-Templated Synthesis of Congested Proline Derivatives via [3 + 2] Cycloaddition Reaction

Abstract An asymmetric synthesis of congested proline derivatives with three defined carbon stereocenters (including two quaternary ones) through an Ag(I)-catalyzed [3 + 2] cycloaddition reaction is described. The atom-economic coupling of a chiral dehydroalanine Ni(II) complex w...