All India Institute of Medical Sciences Bhubaneswar

Lytic Skeletal Lesions with CRAB Features: Metastatic Breast Carcinoma Mimicking Multiple Myeloma on FDG PET/CT

Diffuse marrow infiltration associated with anaemia, hypercalcemia, renal dysfunction, and elevated beta-2 microglobulin typically raises a strong suspicion for multiple myeloma. However, certain solid malignancies may closely mimic this presentation. We report a 57-year-old fema...

Antifungal therapy for newborn infants with invasive fungal infection

RATIONALE: A variety of antifungal drugs, drug preparations and drug combinations are available to treat newborn infants with suspected or confirmed invasive fungal infection. There is a need to assess their relative merits. OBJECTIVES: To evaluate the benefits and harms of treat...

Dysregulation of Serum Magnesium and Glycine N-methyltransferase in Psychiatric Disorders: A Network and Mediation Analysis of Cross-sectional Data

Objective: Magnesium and glycine N-methyltransferase (GNMT) are physiologically interconnected cofactors implicated in neuropsychiatric disorders through effects on N-methyl-D-aspartate receptor function, one-carbon metabolism, and neuronal bioenergetics.However, their simultaneo...

Incremental diagnostic yield of bronchoscopy in non-resolving pneumonia: a prospective observational study from Eastern India

Abstract Background Non-resolving pneumonia (NRP) remains a significant diagnostic challenge because of its diverse etiologies, particularly in tuberculosis-endemic regions. Although a structured non-bronchoscopic evaluation establishes the diagnosis in a substantial proportion o...

34 Therapeutic Targeting of the SLC7A11-GCLM-GPX4 Axis Sensitizes Glioblastoma to Ferroptosis and Associates with Poor Survival

Abstract Background Glioblastoma (GBM) is the most common malignant primary brain tumor with a dismal prognosis. The high proliferative activity of GBM is prone to generating oxidative stress, which must be counteracted to support cell survival and prevent ferroptotic cell death....

Anthropometric Analysis and Assessment of Patient Satisfaction Using Rhinoplasty Outcome Evaluation Questionnaire and NOSE Score in Patients Undergoing Rhinoplasty

Introduction: Anthropometry, derived from Greek origins, loosely translates to measuring the man. The quest for an ‘optimal nose’ that is not just functional but also aesthetically pleasing to the eye is as old as civilisation itself. Nasal analysis is the first and foremost step...

Asymptomatic Hirata syndrome with thionamide use – An underdiagnosed entity

ABSTRACT Hirata syndrome or autoimmune hypoglycemia is a rare cause of hypoglycemia. Patients usually present multiple episodes of postprandial hypoglycemia, usually associated with neuroglycopenic symptoms. This condition has been previously described with multiple drugs such as...