All India Institute of Medical Sciences Bhopal

BUB signaling in cancer and molecular insights into targeted therapies

Abstract The Spindle Assembly Checkpoint (SAC) is vital for proper chromosome segregation during cell division and for maintaining genomic integrity; its disruption can cause aneuploidy and tumors. The BUB gene family ensures SAC fidelity by regulating kinetochore–microtubule att...

Motor neuron disease masquerading as sensorimotor polyneuropathy

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, initially defined as a purely motor neuron disease (MND), marked by the progressive degeneration of motor neurons in the motor cortex, brainstem, and spinal cord. Now it is recognized as a multisystem dise...

Non-pharmacological analgesia and sedation in the pediatric intensive care unit: a narrative review

Abstract Managing pain, anxiety, and agitation in the pediatric intensive care unit (PICU) is often challenging. Pharmacological sedation and analgesia with opioids and benzodiazepines are essential components of PICU management. Although these are effective, they carry risks of...

Association between age of menarche and suicidality: A systematic review and meta-analysis

ABSTRACT Background: Early menarche is associated with increased risks of mental distress, including depression, anxiety, and suicidal behaviors among adolescent girls. Studies suggest that hormonal fluctuations during puberty may contribute to it. The purpose of this review is t...

Endothelial Plasticity as a Continuum in the Tumor Microenvironment

The tumor microenvironment (TME) is a dynamic and complex ecosystem in which endothelial cells (ECs) play a central role beyond their traditional function as passive vascular conduits. Increasing evidence indicates that tumor-associated endothelial cells (TECs) undergo profound p...

Circadian biology and sexual offending: A hypothesis integrating chronobiological rhythms with Routine Activity Theory

Human behavior is temporally organized by endogenous circadian systems and by environmental and social schedules. Sexual motivation, sleep-wake regulation, endocrine function, cognition, and affective processes show time-dependent variation, while criminological research demonstr...

Multiple bee stings leading to a delayed fatal coronary event with probable Kounis syndrome: a case report

Kounis syndrome—an acute coronary syndrome occurring in the setting of allergic or hypersensitivity reactions—remains an under-recognised clinical entity. In many cases, the diagnosis is largely probabilistic, particularly in the absence of confirmatory evidence such as mast-cell...

Psychiatric morbidity and coping in caregivers of patients with substance use disorder

Background Caregivers of patients with substance use disorders often experience psychological distress, but psychiatric morbidity and coping, including religious coping, remain under-studied in Indian treatment settingsObjective To assess psychiatric morbidity, coping strategies,...

Symptomatic Sclerosing Pneumocytoma of Lung: A Diagnostic Challenge with Diverse Morphological Patterns.

Background & Objective: Sclerosing pneumocytoma (SP), formerly termed sclerosing hemangioma, is a rare benign lung neoplasm often detected incidentally. Its histological diversity and dual cell population frequently complicate diagnosis, particularly in small biopsies. Case Prese...

Day-time split study for management of obstructive sleep apnoea: Proof of concept study

Objective: Waiting time for diagnosis and treatment of obstructive sleep apnoea (OSA) is increasing due to a lack of adequate amount of sleep labs. This study was done to find out the feasibility of daytime split Polysomnography (PSG) in patients with excessive daytime sleepiness...

Butterfly gliomas of the corpus callosum: A systematic review of the literature

Objectives: Although rare, butterfly gliomas are notorious for their inferior clinical outcomes. The objective of the present study was to systematically review the available literature regarding the optimal management protocols and prognosis of butterfly glioma based on the avai...

Effectiveness of the Composite Autonomic Symptom Score 31 Scale in Evaluating Autonomic Dysfunction in Diabetic Peripheral Neuropathy: A Comparative Study Using Autonomic Function Testing as Reference

Abstract Background: Autonomic dysfunction is a common yet underdiagnosed complication of diabetic peripheral neuropathy (DPN), contributing to increased morbidity. Early detection is critical for prompt management. The Composite Autonomic Symptom Score 31 (COMPASS-31) is a self-...

Objective Evidence for Mind–body Interventions: Selective Modulation of Meridian-wise Bioelectrical Conductance by Yogic Practices

Abstract Introduction: Traditional Chinese Medicine (TCM) describes meridians as channels through which vital energy (Qi) flows, with disturbances in this flow associated with disease. Contemporary research has demonstrated that classical meridian points possess distinctive elect...