Alexandra Hospital

Integrated Molecular, Clinicopathological and Immune Profiling of Non-Small Cell Lung Cancer: The MONREPOS Hellenic Cooperative Oncology Group (HeCOG) Study (HE_2TR/13)

Integrated assessment of tumour genomics and immune biomarkers may improve prognostic stratification in non-small cell lung cancer (NSCLC). We examined the distribution and prognostic relevance of somatic pathogenic/likely pathogenic variants (PVs), somatic copy-number alteration...

Glucocorticoids: an enemy or a friend for the dermatologist? recommendations for proper use and safe discontinuation

Abstract Purpose Glucocorticoids (GCs) are steroid hormones produced by the adrenal cortex with anti-inflammatory and immunoregulating effects, thus essential for the management of numerous inflammatory and autoimmune disorders, including a wide range of dermatological conditions...

BMAL1 Dysregulation as a Contributing Mechanism Linking Obesity to Oocyte and Endometrial Dysfunction in IVF

Obesity affects nearly one in three women of reproductive age worldwide and consistently reduces success rates in in vitro fertilization, yet the molecular basis for this reduction remains fragmented across separate lines of evidence. Circadian clock genes, particularly BMAL1, or...

The Fibro-Inflammatory Ovary: Stromal Fibrosis, Extracellular Matrix Remodeling, and Mechanotransduction in Female Infertility

Endocrine disorders and inherent flaws in oocyte quality are traditional causes of female infertility. Increasing research indicates that structural and biomechanical alterations in the ovarian microenvironment may significantly contribute to reproductive decline. Progressive ext...

The incremental yield of chromosomal microarray analysis in fetuses with isolated ARSA and normal karyotype: cohort study and meta-analysis of the literature

Aberrant right subclavian artery (ARSA) is a relatively rare ultrasonographic marker that has been associated with trisomy 21 and 22q11.2 deletion. Its predictive accuracy, however, remains arbitrary as published cohorts do not present consistent findings. This study aimed to eva...

BMAL1-Mediated Circadian Regulation of Oocyte Quality and IVF Outcomes

Successful embryo development transpires far before fertilization inside the meticulously regulated microenvironment of the ovarian follicle. Increasing data indicates that circadian regulatory systems influence several processes that define oocyte competence, including mitochond...

Association of non-invasive liver-related scores with cardiovascular disease and a four-domain cardiovascular–renal–hepatic–metabolic phenotype in patients with type 2 diabetes mellitus and MASLD

Abstract Objective Metabolic dysfunction–associated steatotic liver disease (MASLD) is a systemic disorder associated with cardiovascular, renal, and metabolic comorbidities. We evaluated cardiovascular disease (CVD), four-domain cardiovascular–renal–hepatic–metabolic (CRHM) invo...

Patterns and phenotypes of enhanced recovery after surgery implementation in gynaecological oncology: A latent class analysis

Objective: Enhanced recovery after surgery protocols are widely recommended, yet their real-world implementation remains inconsistent due to multiple barriers. This study aimed to characterise implementation patterns during early enhanced recovery after surgery adoption. Methods:...