Alberta Children's Hospital

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS....

IBAS: Interaction-bridged association studies discovering novel genes underlying complex traits

Genetic contributions to complex traits are often mediated through coordinated gene–gene interaction networks, yet most existing association frameworks focus on marginal single-gene effects and overlook higher-order dependency structures. Direct modeling of interactions remains c...

Dr. Tsai et al reply

We appreciate the interest of Drs. Wang and Qu¹ in our work,² and their call for more family-friendly metrics to help convey meaningful quality of life improvements in juvenile idiopathic arthritis ( JIA). After considering the different ideas suggested in t...

Early‐Life Dietary Protein Source Reshapes Gut Microbiota but Fails to Curtail Diet‐Induced Metabolic Syndrome in Young Rats

OBJECTIVE: Dairy consumption plays a protective role in obesity that may be mediated through the gut microbiota. This study examined the role of dairy proteins, casein, whey, and complete dairy (skim milk powder), and a plant-based alternative, soy, on gut microbiota composition,...

Nutrient/ TOR signaling controls adipose mitochondrial transcription factor A ( TFAM ) to regulate organismal growth in Drosophila

Animals must adapt their growth to fluctuations in nutrient availability to ensure proper development. While nutrient-sensing tissues coordinate organismal growth through interorgan signaling, the metabolic changes within these tissues that mediate whole-body growth control remai...

The Association Between Intranasal Steroids and Length of Stay in Children With Orbital Infections

OBJECTIVE: Little is known about the use of intranasal agents in the management of orbital infections in children. This study aims to describe intranasal corticosteroid use in children hospitalized with orbital infections and to determine whether an association exists between int...

Frailty and Surgical Invasiveness Are Independently Associated with Complications in Pediatric Spinal Deformity Surgery

Background: The purposes of this study were to determine whether frailty and surgical invasiveness are independently associated with perioperative outcomes and to describe the outcome rates when these 2 risk domains are considered together in pediatric patients undergoing spinal...

Moving Equity into Practice: Evaluation of an Online Asynchronous Continuing Medical Education Program for Rheumatology Care

Objectives Persistent health inequities exist in the diagnosis, treatment, and outcomes of rheumatologic diseases among at-risk populations in Canada. Prior research identified barriers and facilitators experienced by at-risk populations in Canada when accessing rheumatology care...