Aksaray University

From Sequence to Structure: AlphaFold and the AI Revolution in Aquaculture Drug Discovery and Vaccine Design

Global aquaculture faces an escalating disease and antimicrobial resistance (AMR) crisis, exacerbated by climate-driven physiochemical shifts and intensive farming practices. The integration of artificial intelligence (AI) and structural biology, spearheaded by AlphaFold, represe...

Neurobehavioral Effects of Repeated Low-Dose Dimethyl Sulfoxide Administration in Mice

The aim of study was the neurobehavioral effects of repeated low-dose dimethyl sulfoxide (DMSO) administration in mice. Male Swiss albino mice were randomly divided into four groups: control, DMSO 0.1 mg/kg, DMSO 0.2 mg/kg, and DMSO 0.4 mg/kg (n=6). DMSO was administered intraper...

Explainable seasonal land surface temperature modeling with tree-based machine learning over Menteşe, Türkiye

This study evaluated three tree-based ensembles—Random Forest, XGBoost, and LightGBM—for seasonal modeling of land surface temperature (LST) in the Menteşe district of Muğla, Türkiye, a Mediterranean landscape with pronounced seasonality. Three nested feature sets—a topographic b...

Effects of naringenin on superovulation in mice: evaluation of zygote and blastocyst development, histopathology, and molecular docking insights

CONTEXT: Naringenin is a citrus-derived flavanone with documented antioxidant, anti-inflammatory, and steroidogenic modulatory properties; yet, its effects under gonadotropin-stimulated superovulation have not been investigated. AIMS: This study evaluated the impact of naringenin...

Preoperative Iron Deficiency Anemia and Frailty in Geriatric Colorectal Cancer Surgery: A Prospective Observational Study

Objective: Although iron deficiency anemia (IDA) and frailty are common among geriatric surgical patients—frailty has been reported in approximately 31% of patients undergoing colorectal cancer surgery—prospective data on the association between IDA and frailty in patients underg...

Sodium Hydrosulfide Attenuates Vancomycin-Related Liver Damage in Rats: Roles of Redox Balance, Inflammation, and Cell Death

Vancomycin (VAN), a glycopeptide antibiotic used to treat severe Gram-positive infections, may cause hepatotoxicity at high systemic exposure, limiting its clinical use. Sodium hydrosulfide (NaHS), a water-soluble hydrogen sulfide (H₂S) donor, possesses antioxidant, anti-inflamma...

Impact of Levetiracetam on Hypothalamic-Pituitary-Adrenal Axis Dysregulation, Anxiety-, and Depressive-Like Behaviors in Doxorubicin-Treated Mice

Doxorubicin (DOX) is a highly effective chemotherapeutic agent, yet its clinical utility is frequently compromised by severe neurotoxicity, manifesting as anxiety and depressive-like behaviors. This study investigated the neuroprotective efficacy of the antiepileptic drug levetir...

Retrospective evaluation of neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios in feline panleukopenia

Feline panleukopenia is a severe immunosuppressive viral disease, that particularly affects young cats. This study aimed to evaluate changes in hematological parameters and derived inflammatory indices during the course of feline panleukopenia virus infection. The study included...

Klasik Türk Şiirinde Alçak Gönüllülük

Klasik Türk şiiri, insanın varoluşsal serüvenini, kâinattaki konumunu ve sınırlarını estetik ve felsefi bir bakış açısıyla ele alan köklü bir edebiyat geleneğidir. Bu gelenek bireyin dünyayı anlamlandırmasına imkân tanırken insanın özüne dair sorgulamalara da kılavuzluk eder. Gel...

Natural does not always mean safe: first molecular detection of Cryptosporidium and Acanthamoeba in Iranian spring waters

Abstract Many people perceive spring water as a healthy alternative to tap water. However, unlike treated tap water, which undergoes rigorous filtration and disinfection, untreated or inadequately treated spring water may pose a higher risk of waterborne infections. Here, we anal...

Investigation of the Detection Frequency of Demodex spp. in Marmara University Faculty of Medicine Students According to Mask Use and Personal Hygiene Habits During the COVID-19 Pandemic

Objective: spp. Methods: . Volunteers were asked to complete a questionnaire about their personal hygiene habits. SPSS v.16.0 (IBM Corp., Armonk, NY, USA) software was used to analyse the results. Results: spp. (p=0.036). Conclusion: spp. in the cheeks of individuals using medica...

Strategic visions of local governments in combating the climate crisis: a descriptive study on Türkiye and the EU

The climate crisis, one of the most urgent global challenges of the 21st century, has profound environmental, economic, social, and political consequences. Cities, as the primary sources of greenhouse gas emissions, are central to both mitigation and adaptation strategies. This s...

The effect of proactive personality on professional commitment through career mindfulness in tour guidance students

This study examines the mediating role of career mindfulness (CM) in the relationship between proactive personality (PP) and professional commitment (PC) among Turkish undergraduate students aiming for a career in tour guiding. Despite the importance of PP and mindfulness in care...

Baseline-aware monthly PM10 prediction in Istanbul and Ankara: a city-level panel study comparing persistence, AR(1), and random forest models

Monthly PM 10 prediction was evaluated for Istanbul and Ankara with a 2020 − 2023 city-month panel combining air-quality, meteorological, and traffic-intensity variables. The calendar index comprised 96 city-months, of which 92 had observed PM 10 . Missing PM 10 targets were excl...

Ensemble Machine Learning Predicts Flooding- and Organic Matter-Induced Micronutrient Dynamics in Calcareous Soils

Flooding and farmyard manure (FYM) application trigger complex, non-linear redox reactions that govern micronutrient availability in calcareous soils, yet predictive modelling of these dynamics using machine learning (ML) remains largely unexplored, and the present study was desi...

RDA-ANN Based Real-Time Selective Harmonic Elimination in Multilevel Inverter Fed by PV Panels

This work presents a novel method known as the Red Deer Algorithm-Based Artificial Neural Network (RDA-ANN) for managing real-time voltage and harmonic control in a cascade H-bridge multilevel inverter (CHB-MLI) that is fed by photovoltaic (PV) panels. The RDA-ANN technique propo...

From depth to dynamics: sukuk market development and capital buffer adjustment in Islamic banking systems

Purpose This study aims to examine how sukuk market development is associated with the dynamic adjustment of Islamic banks’ capital adequacy. Design/methodology/approach The analysis uses quarterly, system-level data for Islamic banks across ten countries over Q4-2013 to Q3-2024....

Assessment of end-tidal CO₂ levels in the diagnosis and management of patients with pulmonary embolism

Pulmonary embolism (PE) is a life-threatening emergency associated with acute cardiopulmonary deterioration. This study evaluated the clinical utility of end-tidal carbon dioxide (EtCO₂) for assessing disease severity and monitoring treatment response in high- and intermediate–hi...

ECG-based detection of occlusion myocardial infarction: a dedicated deep neural network versus multimodal large language models and physicians — a retrospective diagnostic accuracy study

Abstract Background Accurate electrocardiogram (ECG) interpretation for acute coronary occlusion is a critical, time-sensitive task in emergency care. The field is increasingly shifting from the ST-segment elevation myocardial infarction paradigm to the broader concept of occlusi...

Architectural and structural examination of the Tekirdağ archaeology museum in Türkiye

This paper presents a comprehensive architectural and structural assessment of the Tekirdağ Archaeology and Ethnography Museum, a heritage building characterised by a mixed structural system consisting of rubble masonry and reinforced concrete additions. Unlike many previous stud...