Akita University

Sugar on the Coat: Site‐Specific O‐ GlcNAc and Myoferlin Adapt COPII for Collagen Export

ABSTRACT Recent work by Hirata and colleagues identifies site‐specific O ‐GlcNAc modification of the cargo‐selecting COPII subunit Sec24D as a dynamic regulatory switch that promotes collagen export from the endoplasmic reticulum (ER), providing new insight into how COPII accommo...

Olive Oil Before Oral Glucose Delays Gastric Emptying and Lowers Glycemia Through Partially Redundant Glucagon and GLP-1 Signaling in Mice

Consumption of fat before carbohydrate (preload) attenuates postprandial glucose excursions, although the underlying mechanisms remain unclear. We investigated whether an olive oil preload (OG) reduces glycemia by engaging endocrine and neural regulation of gastric emptying. Wild...

Renewable Electricity and CO2 Emissions in Tajikistan: Evidence from an ARDL–STIRPAT Framework

Tajikistan relies heavily on hydropower for electricity generation, but increasing energy demand, winter electricity shortages, rising coal consumption, and climate-related changes in water availability pose significant challenges to the country’s energy system and environment. I...

Revision of lymph node classification in the Japanese Classification of Esophageal Cancer and its impact on definitive chemoradiotherapy for stage IV esophageal cancer: a single-institution retrospective study.

The 2022 revision of the Japanese Classification of Esophageal Cancer reclassified certain lymph node metastases previously considered locoregional as distant lymph node metastasis. Consequently, some patients previously diagnosed with stage IVA or III disease and treated with de...

Constrained Minimization for Extracting Unstable Periodic Orbits from Shell-model Turbulence

Developed turbulence represents a canonical example of chaos, whose dynamics can be characterized in terms of invariant solutions embedded within the turbulent attractor. We propose an algorithm for examining such invariant solutions based on a constrained minimization problem. S...

Cr-spinel-hosted inclusions provide evidence for reactive melt transport in layered gabbros from the lower oceanic crust at Hess Deep

Abstract The lower oceanic crust beneath fast-spreading ridges is commonly attributed to fractional crystallization of basaltic melts, but reactive melt transport and crystal-mush reorganization may also be important. We investigated spinel-bearing layered gabbros from Hole U1415...

Impact of adjuvant chemotherapy on renal impairment patients following radical nephroureterectomy in upper tract urothelial carcinoma: a multicenter retrospective study

Abstract To evaluate the impact of adjuvant platinum-based chemotherapy (AC) on oncological outcomes in high-risk upper tract urothelial carcinoma (UTUC) patients with postoperative renal impairment following radical nephroureterectomy (RNU). Among 1050 patients who underwent RNU...

Central spindle instability and ectopic furrow organization mark fragmentation-prone first mitosis in human embryos

Abstract Severe cell fragmentation compromises blastocyst formation and correlates with aneuploidy, but the mitotic events associated with fragmentation remain unclear. Using non-invasive live-cell imaging of DNA, tubulin, and/or actin in discarded human two-pronuclear embryos, h...

Tirzepatide Benefit for Early Glycemic and Weight Management in People with T2D in Japan: Rationale, Design, and Baseline Characteristics of T-BEAT Study

Tirzepatide has demonstrated good efficacy and safety in the management of type 2 diabetes (T2D) in clinical trials. As the importance of early intensive intervention is known, the tirzepatide benefit for early glycemic and weight management (T-BEAT) study investigated the real-w...

Orbital instability for moderately developed Couette turbulence

We perform a long-time Lyapunov analysis of plane Couette turbulence up to friction Reynolds number h Superscript plus Baseline equals 269 h + = 269 $h^+=269$ . The energy of the leading Lyapunov vector is predominantly concentrated in the buffer layer, with characteristic stream...

Recognition-Guided Generative Skeleton Imputation for Robust Action Recognition Under Severe Occlusion in Construction Scenarios

Skeleton-based human action recognition can support digital construction and renovation monitoring by converting worker motions into structured information for safety and process management. However, workers are often occluded by tools, materials, furniture, and temporary structu...

Mapping the past: dynamic local georeferencing for historical cartography

Georeferencing is crucial for integrating historical and pictorial maps into digital environments, enabling their application in research, education, and public engagement. However, traditional GIS-based georeferencing workflows often fall short when applied to these maps, as glo...

Minimally invasive cardiac surgeries in 2023–annual report of the Japanese association for minimally invasive cardiac surgery

Abstract Objective To establish updated nationwide perioperative benchmarks for minimally invasive cardiac surgery (MICS) in Japan by presenting the 2023 annual report and summarizing procedural trends from 2021 to 2023. Methods Data on mitral valve (MV) surgery, aortic valve rep...

P1.095. International Collaborative Study on the Relationship Between ALDH2 Gene Polymorphism and Changes in Salivary Acetaldehyde Concentration by L8020 Lactobacillus

Abstract Topic Esophageal Cancer: Esophageal Carcinogenesis Background Seventy-five percent of the world's esophageal cancer cases occur in Asia. The primary cause is the presence of the flasher (ALDH2 non-inactivating type). The ALDH2 gene polymorphism (rs671 G>A) is believed to...

De-escalation of perioperative systemic therapy for early breast cancer.

Breast cancer is the most common malignancy among women worldwide, and the number of survivors continues to increase owing to earlier detection and advances in treatment. As long-term survivorship becomes increasingly important, minimizing treatment-related toxicity without compr...

Revisiting low-voltage interpretation: Chamber-specific relationships between myocardial wall thickness and omnipolar voltage

Electrogram voltage reflects multiple factors, including viable myocardial mass, structural integrity, electrode configuration, catheter orientation, and activation sequence. How local myocardial wall thickness (WT) contributes to voltage amplitude in structurally intact myocardi...

Pleistocene Basaltic Volcanism on the Fly Platform in Papua New Guinea

Papua New Guinea (PNG) remains one of the least studied regions in the Southwest Pacific, and the tectono-magmatic evolution of extensive areas such as the Fly Platform remains poorly constrained. This study presents the first investigation of basaltic volcanism on the Fly Platfo...

De novo epilepsy after the occipital transtentorial approach: association with occipital lobe injury and persistent FLAIR lesions

The occipital transtentorial approach (OTA) is a useful surgical corridor for deep-seated lesions involving the pineal region, thalamus, ventral temporal structures, and posterior fossa. Although occipital lobe injury is a recognized complication of OTA, its relationship with pos...

Detection of Weld Root Crack in Metal Plates with Convolutional Neural Network

The detection of weld root cracks in metal plates using nonlinear ultrasonics and a convolutional neural network (CNN) was investigated. Lamb waves with a fundamental frequency of 0.5 MHz were transmitted into a carbon steel plate specimen, and the waveforms were recorded using a...

Bone-preserving ankle arthrodesis after infected pilon fracture nonunion: lessons from tapered distal docking and fibular-supported reconstruction

Infected nonunion after severe pilon fracture remains a major challenge in limb reconstruction, particularly when chronic infection and repeated debridement result in severe metaphyseal bone loss and compromised distal tibial morphology. In such cases, conventional resection to c...